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Details on Person ZEB1 recruits a corepressor protein TLE1 (Transducin-like en...

Class:IdSummation:9930706
_displayNameZEB1 recruits a corepressor protein TLE1 (Transducin-like en...
_timestamp2024-12-07 12:58:19
created[InstanceEdit:9930712] Orlic-Milacic, Marija, 2024-12-05
literatureReference[LiteratureReference:9764769] TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression
[LiteratureReference:9815627] TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin
[LiteratureReference:9930710] The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells
modified[InstanceEdit:9930958] Orlic-Milacic, Marija, 2024-12-07
textZEB1 recruits a corepressor protein TLE1 (Transducin-like enhancer of split 1) to the CDH1 gene promoter (Yao et al. 2016, Yao et al. 2017), leading to its deacetylation (Yao et al. 2017). TLE1 was previously shown to recruit histone deacetylase HDAC1 to the human CDH1 gene promoter (Yao et al. 2014), and ZEB1 was also shown to recruit HDAC1 and HDAC2 to the CDH1 gene promoter (Aghdassi et al. 2012).
(summation)[Reaction:9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter [Homo sapiens]
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