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Details on Person F5 R534Q, A540V is not cleaved by activated protein C

Class:IdFailedReaction:9930452
_displayNameF5 R534Q, A540V is not cleaved by activated protein C
_doReleaseTRUE
_timestamp2026-01-27 16:12:36
authored[InstanceEdit:9930429] Shamovsky, Veronica, 2024-12-03
catalystActivity[CatalystActivity:141025] serine-type endopeptidase activity of Activated protein C:Protein S [plasma membrane]
compartment[Compartment:984] extracellular region
created[InstanceEdit:9930429] Shamovsky, Veronica, 2024-12-03
disease[Disease:9668251] thrombophilia
edited[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
entityFunctionalStatus[EntityFunctionalStatus:9930431] loss_of_function of FV R534Q, FV A540V [extracellular region]
input[DefinedSet:9930490] FV R534Q, FV A540V [extracellular region] [Homo sapiens]
internalReviewed[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
literatureReference[LiteratureReference:9930447] Mutation in blood coagulation factor V associated with resistance to activated protein C
[LiteratureReference:9930475] Mechanisms of the factor V Leiden paradox
[LiteratureReference:9930462] Identification and functional characterization of a novel F5 mutation (Ala512Val, FVB onn ) associated with activated protein C resistance
modified[InstanceEdit:9930765] Shamovsky, Veronica, 2024-12-06
[InstanceEdit:9938680] Shamovsky, Veronica, 2025-02-18
[InstanceEdit:9938835] Shamovsky, Veronica, 2025-02-20
[InstanceEdit:9979498] Shamovsky, Veronica, 2026-01-20
[InstanceEdit:9980332] Shamovsky, Veronica, 2026-01-27
nameF5 R534Q, A540V is not cleaved by activated protein C
Defective F5 is not cleaved at a.a.534 by activated protein C
normalReaction
releaseDate2026-03-25
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9930507] R-HSA-9930452.1
summation[Summation:9930438] Under normal physiological conditions, activated protein C (...
(hasEvent)[Pathway:9930449] Defective cleavage of FV variant at a.a.534 [Homo sapiens]
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