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Details on Person F5 R334T, I387T is not cleaved by activated protein C

Class:IdFailedReaction:9930440
_displayNameF5 R334T, I387T is not cleaved by activated protein C
_doReleaseTRUE
_timestamp2026-01-27 16:12:30
authored[InstanceEdit:9930429] Shamovsky, Veronica, 2024-12-03
catalystActivity[CatalystActivity:141025] serine-type endopeptidase activity of Activated protein C:Protein S [plasma membrane]
compartment[Compartment:984] extracellular region
created[InstanceEdit:9930429] Shamovsky, Veronica, 2024-12-03
disease[Disease:9668251] thrombophilia
edited[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
entityFunctionalStatus[EntityFunctionalStatus:9930412] loss_of_function of F5 R334T, F5 I387T [extracellular region]
input[DefinedSet:9930422] F5 R334T, F5 I387T [extracellular region] [Homo sapiens]
internalReviewed[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
literatureReference[LiteratureReference:9930421] Factor V Cambridge: a new mutation (Arg306-->Thr) associated with resistance to activated protein C
[LiteratureReference:9930410] Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis
modified[InstanceEdit:9938680] Shamovsky, Veronica, 2025-02-18
[InstanceEdit:9938835] Shamovsky, Veronica, 2025-02-20
[InstanceEdit:9979497] Shamovsky, Veronica, 2026-01-20
[InstanceEdit:9980331] Shamovsky, Veronica, 2026-01-27
nameF5 R334T, I387T is not cleaved by activated protein C
normalReaction
releaseDate2026-03-25
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9930513] R-HSA-9930440.1
summation[Summation:9930424] Under normal physiological conditions, activated protein C (...
(hasEvent)[Pathway:9930479] Defective cleavage of FV variant at R334 [Homo sapiens]
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No pathways have been reviewed or authored by F5 R334T, I387T is not cleaved by activated protein C (9930440)
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