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Details on Person Cryptochrome (Cry1, Cry2) proteins, Period (Per1, Per2, Per3...
| Class:Id | Summation:9930074 |
|---|---|
| _displayName | Cryptochrome (Cry1, Cry2) proteins, Period (Per1, Per2, Per3... |
| _timestamp | 2025-02-11 01:39:30 |
| created | [InstanceEdit:9930075] May, Bruce, 2024-12-02 |
| modified | [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9936399] May, Bruce, 2025-01-22 [InstanceEdit:9938217] May, Bruce, 2025-02-11 |
| text | Cryptochrome (Cry1, Cry2) proteins, Period (Per1, Per2, Per3) proteins, and a kinase, Csnk1d or Csnk1e (CKIepsilon or CKIdelta), form a complex in the cytosol (Griffin et al. 1999, Kume et al. 1999, Field et al. 2000, Vielhaber et al. 2000, Eide et al. 2002, Lee et al. 2004, Lee et al. 2009, Nangle et al. 2014, Cao et al. 2023). Cry1, Cry2, Per1, Per2, Per3 and kinases assemble into a single large complex which enters the nucleus and binds Bmal1:Clock heterodimers (Aryal et al. 2017, Cao et al. 2023). The cytosolic complex is measured as 0.9-1.1 mDa (Aryal et al. 2017) and the nuclear complex is measured as 1.9 MDa (Aryal et al. 2017) or 707 kDa (Cao et al. 2023). Cry proteins contain nuclear localization signals, bind Per proteins (Kume et al. 1999, Nangle et al. 2014), and cause translocation of the complex into the nucleus (Kume et al. 1999). Phosphorylation of Per2 on serine-394 (serine-396 of the human homolog) by Cdk5 during the day increases the interaction between Per2 and Cry1 (Brenna et al. 2019). The association between Csnk1e and Per1 appears to mask a nuclear localization signal in Per1 and makes nuclear translocation of Per1 dependent on phosphorylation of Per1 (Vielhaber et al. 2000). Csnk1e binds and phosphorylates Per2 (Vielhaber et al. 2000). Per3 does not directly interact with Csnk1e (Lee et al. 2004). Csnk1e also phosphorylates Cry proteins and the phosphorylation is dependent on the interaction between Cry proteins and Per proteins, which may act as scaffolds (Eide et al. 2002). |
| (summation) | [BlackBoxEvent:9909360] Formation of Cry:Per:Kinase complex [Mus musculus] |
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No pathways have been reviewed or authored by Cryptochrome (Cry1, Cry2) proteins, Period (Per1, Per2, Per3... (9930074)
