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Details on Person Phosphorylated Bmal1:Clock heterodimers bound to the promote...
| Class:Id | Summation:9929990 |
|---|---|
| _displayName | Phosphorylated Bmal1:Clock heterodimers bound to the promote... |
| _timestamp | 2025-01-10 16:18:16 |
| created | [InstanceEdit:9929960] May, Bruce, 2024-11-30 |
| literatureReference | [LiteratureReference:549365] The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker |
| modified | [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9934784] May, Bruce, 2025-01-10 |
| text | Phosphorylated Bmal1:Clock heterodimers bound to the promoter of the Nr1d1 (Rev-erba) gene (Onishi et al. 2007) coactivated by Ppargc1a (Liu, Li et al. 2007) activate transcription, resulting in a circadian rhythm of expression in the suprachiasmatic nucleus (Onishi et al. 2002), liver, and kidney that peaks at mid-day (Yamamoto et al. 2004, Liu, Cai et al. 2007, and inferred from rat in Triqueneaux et al. 2004). Oscillation of expression is also observed in cultured cells in response to serum shock (Rogers et al. 2008). |
| (summation) | [BlackBoxEvent:9926623] Phosphorylated Bmal1:Clock positively regulates expression of Nr1d1 [Mus musculus] |
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No pathways have been reviewed or authored by Phosphorylated Bmal1:Clock heterodimers bound to the promote... (9929990)
