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Details on Person Phosphorylated BMAL1:CLOCK heterodimers bound to the promote...
| Class:Id | Summation:9929988 |
|---|---|
| _displayName | Phosphorylated BMAL1:CLOCK heterodimers bound to the promote... |
| _timestamp | 2025-01-24 16:40:49 |
| created | [InstanceEdit:9929960] May, Bruce, 2024-11-30 |
| literatureReference | [LiteratureReference:549365] The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker [LiteratureReference:5667131] Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism [LiteratureReference:9933177] Circadian clock genes and the transcriptional architecture of the clock mechanism [LiteratureReference:1368164] Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha [LiteratureReference:9936571] REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis |
| modified | [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9934287] May, Bruce, 2025-01-07 [InstanceEdit:9934784] May, Bruce, 2025-01-10 [InstanceEdit:9936399] May, Bruce, 2025-01-22 [InstanceEdit:9936574] May, Bruce, 2025-01-23 [InstanceEdit:9936591] May, Bruce, 2025-01-24 [InstanceEdit:9936612] May, Bruce, 2025-01-24 |
| text | Phosphorylated BMAL1:CLOCK heterodimers bound to the promoter of the NR1D1 (REV-ERBA) gene and coactivated by PPARGC1A (PGC-1alpha) activate transcription, resulting in a circadian rhythm of expression in suprachiasmatic nucleus, liver, and kidney that peaks at mid-day in mice (inferred from mouse homologs, and inferred from rat in Triqueneaux et al. 2004). Transcription of the NR1D1 gene occurs on the opposite strand of the ERBA gene (Lazar et al.1990). Oscillation of NR1D1 expression is also observed in cultured cells in response to serum shock (inferred from mouse cells). In the human brain, expression of NR1D1 peaks in the early morning, before the peak of PER1 expression (Li et al. 2013) and earlier than the peak of expression of mouse Nr1d1. NR1D1 acts as a heme sensor that represses transcription of genes in response to heme and time of day (reviewed in Yin et al. 2010). Notably NR1D1:heme represses transcription of PPARG1CA, a positive regulator of heme biosynthesis, thus maintaining heme homeostasis (Wu et al. 2009). NR1D1:heme also regulates transcription of INSIG1 and INSIG2 (inferred from mouse homologs in Martelot et al. 2009), sterol sensors that interact with SREBF1 (SREBP1), an activator of sterol biosynthesis. NR1D1 is a component of the secondary loop of the circadian clock which regulates expression of BMAL1, CLOCK, and NPAS2 (reviewed in Cox and Takahashi 2019). |
| (summation) | [BlackBoxEvent:9923018] Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA) [Homo sapiens] |
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No pathways have been reviewed or authored by Phosphorylated BMAL1:CLOCK heterodimers bound to the promote... (9929988)
