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Details on Person CCNA2:CDK1 complex was reported to phosphorylate CDC25B in l...
| Class:Id | Summation:9929942 |
|---|---|
| _displayName | CCNA2:CDK1 complex was reported to phosphorylate CDC25B in l... |
| _timestamp | 2024-11-30 02:15:24 |
| created | [InstanceEdit:9929941] Orlic-Milacic, Marija, 2024-11-30 |
| literatureReference | [LiteratureReference:9929665] Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability [LiteratureReference:9929937] Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation |
| text | CCNA2:CDK1 complex was reported to phosphorylate CDC25B in late G2, targeting it for proteasome-mediated degradation, which is an important step for G2/M transition (Baldin et al. 1997). While CCNB1:CDK1 and CCNA2:CDK2 can also phosphorylate CDC25B, the phosphorylated residues likely differ for the three CDK2 complexes, based on differences in migration of phosphorylated CDC25B in denaturing polyacrylamide gels, and only CCNA2:CDK1-mediated phosphorylation leads to proteasomal degradation of CDC25B (Baldin et al. 1997). CDC25B (MPIP2) was also reproducibly identified as a target of the CCNA2:CDK1 complex in a high-throughput study (Dumitru et al. 2017). |
| (summation) | [Reaction:9929935] CCNA:CDK1 phosphorylates CDC25B [Homo sapiens] |
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No pathways have been reviewed or authored by CCNA2:CDK1 complex was reported to phosphorylate CDC25B in l... (9929942)
