Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person CCNA:CDK1 phosphorylates WEE1

Class:IdReaction:9929535
_displayNameCCNA:CDK1 phosphorylates WEE1
_doReleaseTRUE
_timestamp2025-02-26 22:23:09
authored[InstanceEdit:9929531] Orlic-Milacic, Marija, 2024-11-26
catalystActivity[CatalystActivity:9929667] cyclin-dependent protein serine/threonine kinase activity of p-S-CCNA:p-T161-CDK1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9929534] Orlic-Milacic, Marija, 2024-11-26
edited[InstanceEdit:9936325] Orlic-Milacic, Marija, 2025-01-22
input[EntityWithAccessionedSequence:69253] WEE1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:9928910] Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts
[LiteratureReference:9929507] Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery
[LiteratureReference:9929665] Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability
modified[InstanceEdit:9929678] Orlic-Milacic, Marija, 2024-11-27
[InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18
[InstanceEdit:9936323] Orlic-Milacic, Marija, 2025-01-22
[InstanceEdit:9939407] Orlic-Milacic, Marija, 2025-02-26
[InstanceEdit:9939408] Orlic-Milacic, Marija, 2025-02-26
nameCCNA:CDK1 phosphorylates WEE1
output[EntityWithAccessionedSequence:9929669] p-T187,T190-WEE1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2025-03-26
reviewed[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9929537] R-HSA-9929535.1
structureModified[InstanceEdit:9929678] Orlic-Milacic, Marija, 2024-11-27
summation[Summation:9929674] CCNA2 binds to WEE1 in G2 (Pagliuca et al. 2011) and the CCN...
(hasEvent)[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(replacementInstances)[_Deleted:9953045] Deletion of instance: 69756
[_Deleted:9953047] Deletion of instance: 69754
[Change default viewing format]
No pathways have been reviewed or authored by CCNA:CDK1 phosphorylates WEE1 (9929535)