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Details on Person CD274 ubiquitination by SPOP:CUL3:RBX1 complex

Class:Id	Reaction:9929490
_displayName	CD274 ubiquitination by SPOP:CUL3:RBX1 complex
_doRelease	TRUE
_timestamp	2025-08-26 07:56:53
authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
catalystActivity	[CatalystActivity:9929488] ubiquitin protein ligase activity of SPOP:CUL3:RBX1:CD274 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9929494] Tiwari, Krishna, 2024-11-26
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
input	[Complex:9929493] SPOP:CUL3:RBX1:CD274 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9935361] Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance [LiteratureReference:9935375] CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein
modified	[InstanceEdit:9929505] Tiwari, Krishna, 2024-11-26 [InstanceEdit:9935393] Tiwari, Krishna, 2025-01-14 [InstanceEdit:9937955] Tiwari, Krishna, 2025-02-10 [InstanceEdit:9938512] Tiwari, Krishna, 2025-02-17 [InstanceEdit:9963582] Gillespie, Marc E, 2025-08-14 [InstanceEdit:9964108] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964125] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964126] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	CD274 ubiquitination by SPOP:CUL3:RBX1 complex
output	[Complex:9929485] polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol] [Homo sapiens]
releaseDate	2025-09-18
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9929504] R-HSA-9929490.1
structureModified	[InstanceEdit:9938512] Tiwari, Krishna, 2025-02-17
summation	[Summation:9937954] SPOP:CUL3:RBX1 E3-ubiquitin ligase complex polyubiquitinates...
(hasEvent)	[Pathway:9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) [Homo sapiens]
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No pathways have been reviewed or authored by CD274 ubiquitination by SPOP:CUL3:RBX1 complex (9929490)