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Details on Person After entering the nucleus from the cytosol, p-S97-Bmal1:p-T...
| Class:Id | Summation:9929324 |
|---|---|
| _displayName | After entering the nucleus from the cytosol, p-S97-Bmal1:p-T... |
| _timestamp | 2025-01-24 16:40:34 |
| created | [InstanceEdit:9929329] May, Bruce, 2024-11-24 |
| literatureReference | [LiteratureReference:9929265] Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein |
| modified | [InstanceEdit:9933436] May, Bruce, 2024-12-30 [InstanceEdit:9934287] May, Bruce, 2025-01-07 [InstanceEdit:9936612] May, Bruce, 2025-01-24 |
| text | After entering the nucleus from the cytosol, p-S97-Bmal1:p-T451,T461-Clock heterodimers bind two E-boxes in the promoter of the Cry1 gene (Etchegaray et al. 2003, Mongrain et al. 2011, Rey et al. 2011, Koike et al. 2012, Chiou et al. 2016, Zhao et al. 2024). Kmt2a (Mll1) associates with Clock and is found at E-box promoter elements (Katada and Sassone-Corsi 2010). Kmt2a is a component of Mll1 histone acetyltransferase complexes, however, the association of other components of the Mll1 complex with Clock has not been demonstrated. The histone acetyltransferase Crebbp (Cbp) interacts with Bmal1 (Garg et al. 2019), however, the presence of Crebbp or Ep300 at the Cry1 promoter was not detected (Koike et al. 2012). Cry1 is a repressor of transcription activation by the p-S97-Bmal1:p-T451,T461-Clock heterodimer and thereby initiates the negative phase of the circadian cycle. Npas2 acts redundantly with Clock to form heterodimers with Bmal1 and regulate Cry1 expression (Reick et al. 2001). |
| (summation) | [Reaction:9926600] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 and coactivators bind the Cry1 gene [Mus musculus] |
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No pathways have been reviewed or authored by After entering the nucleus from the cytosol, p-S97-Bmal1:p-T... (9929324)
