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Details on Person Diagram of Rotavirus A (RV-A) attachment and entry

Class:IdPathwayDiagram:9929197
_displayNameDiagram of Rotavirus A (RV-A) attachment and entry
_timestamp2025-07-16 14:56:18
created[InstanceEdit:9929196] Gillespie, Marc E, 2024-11-21
height915
modified[InstanceEdit:9932288] Gillespie, Marc E, 2024-12-18
[InstanceEdit:9932935] Gillespie, Marc E, 2024-12-20
[InstanceEdit:9954636] Orlic-Milacic, Marija, 2025-06-07
[InstanceEdit:9955139] Orlic-Milacic, Marija, 2025-06-10
[InstanceEdit:9955273] Orlic-Milacic, Marija, 2025-06-10
[InstanceEdit:9955274] Orlic-Milacic, Marija, 2025-06-10
[InstanceEdit:9955314] Orlic-Milacic, Marija, 2025-06-10
[InstanceEdit:9956565] Orlic-Milacic, Marija, 2025-06-13
[InstanceEdit:9956590] Orlic-Milacic, Marija, 2025-06-13
[InstanceEdit:9956787] Orlic-Milacic, Marija, 2025-06-13
[InstanceEdit:9956883] Orlic-Milacic, Marija, 2025-06-16
[InstanceEdit:9957236] Orlic-Milacic, Marija, 2025-06-17
[InstanceEdit:9957251] Orlic-Milacic, Marija, 2025-06-17
[InstanceEdit:9957255] Orlic-Milacic, Marija, 2025-06-17
[InstanceEdit:9957257] Orlic-Milacic, Marija, 2025-06-17
[InstanceEdit:9958083] Orlic-Milacic, Marija, 2025-06-19
[InstanceEdit:9958090] Orlic-Milacic, Marija, 2025-06-19
[InstanceEdit:9958094] Orlic-Milacic, Marija, 2025-06-19
[InstanceEdit:9958101] Orlic-Milacic, Marija, 2025-06-19
[InstanceEdit:9958401] Orlic-Milacic, Marija, 2025-06-19
[InstanceEdit:9958420] Orlic-Milacic, Marija, 2025-06-19
[InstanceEdit:9958438] Orlic-Milacic, Marija, 2025-06-20
[InstanceEdit:9958446] Orlic-Milacic, Marija, 2025-06-20
[InstanceEdit:9958456] Orlic-Milacic, Marija, 2025-06-20
[InstanceEdit:9958457] Orlic-Milacic, Marija, 2025-06-20
[InstanceEdit:9958484] Orlic-Milacic, Marija, 2025-06-20
[InstanceEdit:9960602] Orlic-Milacic, Marija, 2025-07-16
representedPathway[Pathway:9819341] Rotavirus A (RV-A) attachment and entry [Homo sapiens]
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hideComponents="true"> <Properties> <displayName>RV-A TLP VP5*:VP8*</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="9" reactomeId="9945618" position="309 23" bounds="265 11 89 24" textPosition="265 12" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>VP4(232-241)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="10" reactomeId="9945626" position="354 59" bounds="309 48 90 23" textPosition="309 48" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>VP4(242-247)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="11" reactomeId="9945605" position="215 61" bounds="188 48 54 26" textPosition="190 50"> <Properties> <displayName>Trypsin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="13" reactomeId="9953489" position="514 38" bounds="464 18 100 40" textPosition="471 13"> <Properties> <displayName>(HBGAs, Sialyated gangliosides)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="14" reactomeId="9954035" position="520 140" bounds="475 119 90 42" textPosition="475 122" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>RV-A-binding host integrins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="15" reactomeId="9954538" position="833 149" bounds="778 124 111 51" textPosition="777 125" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>RV-A TLP VP5*:VP*8 attached to host enterocyte</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="16" reactomeId="936508" position="659 143" bounds="634 132 50 23" textPosition="635 132"> <Properties> <displayName>HSPA8</displayName> 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</Properties> <Components> <Component id="209" /> <Component id="257" /> <Component id="300" /> <Component id="995" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="228" reactomeId="9955261" position="634 797" bounds="569 785 131 24" textPosition="572 787" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableCompartment id="229" reactomeId="171907" position="614 807" bounds="500 753 228 108" textPosition="513 810" bgColor="250 240 240" lineColor="255 153 102" insets="510 763 212 84"> <Properties> <displayName>endosome lumen</displayName> </Properties> <Components> <Component id="228" /> <Component id="545" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="237" reactomeId="173031" position="1062 814" bounds="895 751 334 126" textPosition="906 833" bgColor="250 240 240" lineColor="255 153 102" insets="903 761 313 109"> <Properties> <displayName>late endosome lumen</displayName> </Properties> <Components> <Component id="239" /> <Component id="1156" /> <Component id="1157" /> <Component id="1158" /> <Component id="1159" /> <Component id="1163" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="239" reactomeId="9955266" position="980 805" bounds="928 787 105 37" textPosition="932 788" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.ProcessNode id="255" reactomeId="9819327" position="1137 513" bounds="1063 464 148 99" textPosition="1068 477" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 51" lineWidth="1.0"> <Properties> <displayName>Rotavirus A (RV-A) genome replication, transcription and translation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="257" reactomeId="8875316" position="633 539" bounds="585 528 96 23" textPosition="585 529" bgColor="204 255 255" 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textPosition="1187 750"> <Properties> <displayName>M6PR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1158" reactomeId="9958429" position="1102 846" bounds="1059 836 87 20" textPosition="1059 835"> <Properties> <displayName>CTSB(80-333)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1159" reactomeId="9958431" position="1145 784" bounds="1123 774 45 21" textPosition="1127 774"> <Properties> <displayName>CTSS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1163" reactomeId="9958397" position="1210 791" bounds="1187 781 47 20" textPosition="1189 780"> <Properties> <displayName>IGF2R</displayName> </Properties> </org.gk.render.RenderableProtein> </Nodes> <Edges> <org.gk.render.RenderableReaction id="6" reactomeId="9920465" points="145 104, 213 113, 231 112" position="213 113" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="7" /> </Inputs> <Outputs> <Output id="8" points="324 104" /> <Output id="9" points="298 38" /> <Output id="10" points="327 74" /> </Outputs> <Catalysts> <Catalyst id="11" points="214 80" /> </Catalysts> <Properties> <displayName>Gut trypsin cleavage of VP4 to yield VP5* and VP8* spike subunits</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="9944133" points="626 99, 671 97, 775 131" position="671 97" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="8" points="459 99" /> <Input id="14" points="571 122" /> <Input id="13" points="550 64" /> <Input id="16" points="650 129" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Activators> <Activator id="50" points="674 39" /> </Activators> <Properties> <displayName>RV-A virion attaches to an enterocyte</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="9954891" points="775 171, 547 266, 492 315" position="547 266" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="168" /> </Outputs> <Activators> <Activator id="138" points="705 155" /> <Activator id="16" points="648 158" /> <Activator id="169" points="404 155" /> <Activator id="171" points="596 160" /> <Activator id="342" points="968 151" /> </Activators> <Properties> <displayName>Clathrin-dependent endocytosis of RV-A TLP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="172" reactomeId="9954894" points="825 178, 796 268, 763 370" position="796 268" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="137" /> </Outputs> <Activators> <Activator id="138" points="727 155" /> <Activator id="16" points="671 158" /> <Activator id="171" points="625 156" /> <Activator id="390" points="1083 389, 917 429" /> <Activator id="342" points="1002 156, 960 246" /> </Activators> <Properties> <displayName>Clathrin-independent endocytosis of RV-A TLP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="191" reactomeId="9819328" points="835 178, 842 231, 897 482" position="842 231" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Properties> <displayName>Rotavirus A (RVA) entry via direct membrane penetration</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="208" reactomeId="9955262" points="759 407, 759 496, 647 587" position="759 496" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="209" /> </Outputs> <Activators> <Activator id="257" points="666 525" /> <Activator id="300" points="652 509" /> <Activator id="450" points="639 453" /> <Activator id="990" points="629 352" /> <Activator id="995" points="665 484" /> </Activators> <Properties> <displayName>RV-A TLP transitions from non-coated endocytic vesicle to early endosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="210" reactomeId="9954896" points="474 352, 463 497, 615 587" position="463 497" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="168" /> </Inputs> <Outputs> <Output id="209" /> </Outputs> <Activators> <Activator id="257" points="586 525" /> <Activator id="450" points="575 453" /> <Activator id="990" points="598 352" /> <Activator id="995" points="593 484" /> <Activator id="300" points="608 510" /> </Activators> <Properties> <displayName>RV-A TLP transitions from clathrin-coated endocytic vesicle to early endosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="227" reactomeId="9954890" points="633 616, 631 702, 633 782" position="631 702" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="209" /> </Inputs> <Outputs> <Output id="228" /> </Outputs> <Activators> <Activator id="534" points="669 702" /> <Activator id="538" points="570 703" /> <Activator id="545" points="551 746" /> </Activators> <Properties> <displayName>RV-A TLP transitions to mature endosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="233" reactomeId="9954895" points="657 782, 835 695, 895 520" position="835 695" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="228" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Properties> <displayName>Release of RV-A DLP to cytosol from mature endosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="238" reactomeId="9954893" points="703 808, 821 831, 925 813" position="821 831" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="228" /> </Inputs> <Outputs> <Output id="239" /> </Outputs> <Activators> <Activator id="1054" points="799 773" /> <Activator id="1055" points="883 734" /> </Activators> <Properties> <displayName>RV-A TLP transitions to late endosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="256" interactionType="Activate" points="932 502, 1060 509" position="996 505" lineWidth="2.0" lineColor="255 51 51"> <Inputs> <Input id="192" /> </Inputs> <Outputs> <Output id="255" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="339" reactomeId="9956766" points="1156 147, 1112 147, 1088 149" position="1112 147" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="340" points="1181 146" /> <Input id="341" points="1160 180" /> </Inputs> <Outputs> <Output id="342" points="1049 144" /> <Output id="343" points="1077 172" /> </Outputs> <Catalysts> <Catalyst id="344" points="1114 209" /> </Catalysts> <Activators> <Activator id="15" points="850 121, 892 62, 1085 64" /> </Activators> <Properties> <displayName>RV-A-activated CDC42 GEFs activate CDC42</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="387" reactomeId="9956768" points="1073 285, 1127 279, 1199 264" position="1127 279" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="342" points="1013 156" /> <Input id="388" points="1063 305" /> </Inputs> <Outputs> <Output id="389" points="1215 309" /> <Output id="340" points="1220 163" /> </Outputs> <Catalysts> <Catalyst id="390" points="1123 367" /> </Catalysts> <Activators> <Activator id="15" points="858 178, 1060 372" /> </Activators> <Properties> <displayName>ARHGAP31 stimulates CDC42 GTPase activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="989" reactomeId="9958086" points="650 320, 677 311, 730 318" position="677 311" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="990" /> </Inputs> <Catalysts> <Catalyst id="991" points="645 299" /> </Catalysts> <Activators> <Activator id="15" points="800 178, 706 249" /> <Activator id="342" points="979 156, 728 254" /> </Activators> <Properties> <displayName>26S proteasome-mediated degradation of PARD6B:aPKC in response to RV-A attachment</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1155" reactomeId="9954889" points="975 784, 940 652, 905 520" position="940 652" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="239" /> </Inputs> <Outputs> <Output id="192" /> </Outputs> <Activators> <Activator id="1156" points="1126 805" /> <Activator id="1157" points="1181 747" /> <Activator id="1158" points="1093 833" /> <Activator id="1159" points="1128 771" /> <Activator id="1163" points="1190 778" /> </Activators> <Properties> <displayName>Release of RV-A DLP to cytosol from late endosome</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Rotavirus A (RV-A) attachment and entry (9929197)
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