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Cyclin A (CCNA) binds to Cyclin-dependent kinase 2 (CDK2)...
| Class:Id | Summation:9928893 |
|---|---|
| _displayName | Cyclin A (CCNA) binds to Cyclin-dependent kinase 2 (CDK2)... |
| _timestamp | 2024-11-18 17:50:20 |
| created | [InstanceEdit:9928876] Orlic-Milacic, Marija, 2024-11-18 |
| literatureReference | [LiteratureReference:9928866] Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells |
| modified | [InstanceEdit:9928914] Orlic-Milacic, Marija, 2024-11-18 |
| text | Cyclin A (CCNA) binds to Cyclin-dependent kinase 2 (CDK2) (Merrick et al. 2008, Deibler and Kirschner 2010) throughout G1 and S phase in human cells (Merrick et al. 2008), showing a preferrential binding to CDK2 over CDK1 despite a ~10-fold greater abundance of CDK1 relative to CDK2 (Merrick et al. 2008). The two antibodies used in the study by Merrick et al. 2008 were raised against CCNA2, but it is not clear whether they distinguish between CCNA1 and CCNA2. |
| (summation) | [Reaction:9928885] Formation of CCNA2:CDK2 complex [Homo sapiens] |
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Cyclin A (CCNA) binds to Cyclin-dependent kinase 2 (CDK2)... (9928893)
