Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person
Cyclin A2 (CCNA2) forms a complex with Cyclin-dependent k...
| Class:Id | Summation:9928871 |
|---|---|
| _displayName | Cyclin A2 (CCNA2) forms a complex with Cyclin-dependent k... |
| _timestamp | 2024-11-19 16:37:59 |
| created | [InstanceEdit:9928876] Orlic-Milacic, Marija, 2024-11-18 |
| literatureReference | [LiteratureReference:9928897] Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase [LiteratureReference:9928866] Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells [LiteratureReference:9928884] Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [LiteratureReference:9928910] Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts |
| modified | [InstanceEdit:9928913] Orlic-Milacic, Marija, 2024-11-18 [InstanceEdit:9929025] Orlic-Milacic, Marija, 2024-11-19 |
| text | Cyclin A2 (CCNA2) forms a complex with Cyclin-dependent kinase 1 (CDK1, also known as Cdc2) (Lees and Harlow 1993, Merrick et al. 2008, Joshi et al. 2009, Deibler and Kirschner 2010), resulting in the triggering of CDK1 catalytic activity (Lees and Harlow 1993). Two regions within the conserved cyclin box domain of CCNA2, encompassing amino acid residues 189-241 and 275-320, are involved in binding to CDK1 (Lees and Harlow 1993). In human cells, it was shown that Cyclin A (CCNA) preferentially binds to CDK2 throughout G1 and S phases, and only starts binding to CDK1 after no more CDK2 is available, despite a ~10-fold greater abundance of CDK1 relative to CDK2 (Merrick et al. 2008). The two antibodies used in the study by Merrick et al. 2008 were raised against CCNA2, but it is not clear whether they distinguish between CCNA1 and CCNA2. |
| (summation) | [Reaction:9928887] Formation of CCNA2:CDK1 complex [Homo sapiens] |
| [Change default viewing format] | |
Cyclin A2 (CCNA2) forms a complex with Cyclin-dependent k... (9928871)
