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Cyclin A1 (CCNA1) forms a complex with Cyclin-dependent k...
| Class:Id | Summation:9928864 |
|---|---|
| _displayName | Cyclin A1 (CCNA1) forms a complex with Cyclin-dependent k... |
| _timestamp | 2024-11-19 16:37:58 |
| created | [InstanceEdit:9928876] Orlic-Milacic, Marija, 2024-11-18 |
| literatureReference | [LiteratureReference:9928884] Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2 [LiteratureReference:9928870] Cyclin A1 expression in leukemia and normal hematopoietic cells [LiteratureReference:9928883] Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines [LiteratureReference:9928862] A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer |
| modified | [InstanceEdit:9929025] Orlic-Milacic, Marija, 2024-11-19 |
| text | Cyclin A1 (CCNA1) forms a complex with Cyclin-dependent kinase 1 (CDK1) (Wegiel et al. 2005, Joshi et al. 2009) that is catalytically active (Joshi et al. 2009). The amino acid sequence of CCNA1 is only 48% identical to that of CCNA2 (Yang et al. 1997). In contrast to CCNA2, which is ubiquitously expressed, CCNA1 shows a restricted pattern of expression, being detectable in testis (Yang et al. 1997) and brain (Yang et al. 1997) by Northern blot analysis, as well as in acute myeloid leukemia (AML) cell lines (Yang et al. 1997, Yang et al. 1999) and in normal CD34+ hematopoietic progenitor cells (Yang et al. 1999). |
| (summation) | [Reaction:9928875] Formation of CCNA1:CDK1 complex [Homo sapiens] |
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Cyclin A1 (CCNA1) forms a complex with Cyclin-dependent k... (9928864)
