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Query author contributions in Reactome

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Details on Person Diagram of DDX58/IFIH1-mediated induction of interferon-alpha/beta

Class:IdPathwayDiagram:992776
_displayNameDiagram of DDX58/IFIH1-mediated induction of interferon-alpha/beta
_timestamp2024-11-10 17:58:57
created[InstanceEdit:992772] Garapati, P V, 2010-11-04
height1101
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1845388] Jupe, S, 2011-10-28
[InstanceEdit:5624322] Garapati, P V, 2014-09-25
[InstanceEdit:6791278] Garapati, Phani Vijay, 2015-08-20
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8952685] Jupe, Steve, 2016-12-16
[InstanceEdit:8983918] Jupe, Steve, 2017-03-31
[InstanceEdit:9014554] Shamovsky, Veronica, 2017-08-01
[InstanceEdit:9038425] Shamovsky, Veronica, 2018-02-26
[InstanceEdit:9038676] Orlic-Milacic, Marija, 2018-03-13
[InstanceEdit:9038683] Orlic-Milacic, Marija, 2018-03-13
[InstanceEdit:9038753] Orlic-Milacic, Marija, 2018-03-14
[InstanceEdit:9603339] Orlic-Milacic, Marija, 2018-03-19
[InstanceEdit:9603346] Orlic-Milacic, Marija, 2018-03-19
[InstanceEdit:9603349] Orlic-Milacic, Marija, 2018-03-19
[InstanceEdit:9603353] Orlic-Milacic, Marija, 2018-03-20
[InstanceEdit:9604505] Shamovsky, Veronica, 2018-04-03
[InstanceEdit:9604595] Shamovsky, Veronica, 2018-04-04
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9687068] Shamovsky, Veronica, 2020-05-06
[InstanceEdit:9687805] Shamovsky, Veronica, 2020-05-12
[InstanceEdit:9687806] Shamovsky, Veronica, 2020-05-12
[InstanceEdit:9697792] Matthews, Lisa, 2020-08-21
[InstanceEdit:9699037] Matthews, Lisa, 2020-09-09
[InstanceEdit:9714222] Shamovsky, Veronica, 2021-02-08
[InstanceEdit:9715437] Shamovsky, Veronica, 2021-02-17
[InstanceEdit:9716560] Shamovsky, Veronica, 2021-02-22
[InstanceEdit:9716568] Shamovsky, Veronica, 2021-02-22
[InstanceEdit:9716610] D'Eustachio, Peter, 2021-02-22
[InstanceEdit:9767861] Shamovsky, Veronica, 2022-03-01
[InstanceEdit:9768026] Shamovsky, Veronica, 2022-03-03
[InstanceEdit:9773900] Shamovsky, Veronica, 2022-05-10
[InstanceEdit:9796644] Shamovsky, Veronica, 2022-08-10
[InstanceEdit:9833456] Stephan, Ralf, 2023-04-26
[InstanceEdit:9852735] Stephan, Ralf, 2023-11-06
[InstanceEdit:9853048] Shamovsky, Veronica, 2023-11-09
[InstanceEdit:9853099] Matthews, Lisa, 2023-11-14
[InstanceEdit:9927416] Shamovsky, Veronica, 2024-11-05
[InstanceEdit:9927580] Matthews, Lisa, 2024-11-08
[InstanceEdit:9927964] Shamovsky, Veronica, 2024-11-10
representedPathway[Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta [Homo sapiens]
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position="1035 483" bounds="1011 472 48 23" textPosition="1011 472"> <Properties> <displayName>NLRC5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="492" reactomeId="937325" position="911 514" bounds="851 468 121 93" textPosition="851 469" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="525" reactomeId="983457" position="694 971" bounds="671 960 46 23" textPosition="671 960"> <Properties> <displayName>PCBP2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="526" reactomeId="983462" position="577 892" bounds="514 860 126 65" textPosition="514 861" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2</displayName> 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125 45" textPosition="2578 1013" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>SARS-CoV-2-host interactions</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="2606" reactomeId="9754834" position="1551 638" bounds="1524 627 54 23" textPosition="1524 628" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>M:TBK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2628" reactomeId="9729447" position="1332 547" bounds="1299 536 67 23" textPosition="1299 537" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TRIM25:N</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="2630" reactomeId="9705683" position="1619 589" bounds="1557 567 125 45" textPosition="1557 567" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.ProcessNode id="2635" reactomeId="9833110" position="1849 302" bounds="1808 280 83 45" textPosition="1808 280" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>RSV-host interactions</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="2638" reactomeId="9833449" position="2264 272" bounds="2224 261 80 23" textPosition="2224 262" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>CREBBP:NS1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2639" reactomeId="9833445" position="2355 273" bounds="2325 262 61 23" textPosition="2325 263" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>IRF3:NS1</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="8" reactomeId="168935" points="1586 499, 1563 499, 1534 498" position="1563 499" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1851" stoichiometry="2" points="1619 521" /> <Input id="11" stoichiometry="2" points="1685 499" /> <Input id="1852" stoichiometry="2" points="1606 473" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Inhibitors> <Inhibitor id="13" points="1553 401" /> <Inhibitor id="445" points="1839 432, 1740 554, 1562 556" /> </Inhibitors> <Properties> <displayName>viral dsRNA binds DDX58</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="913725" points="1142 400, 1106 399, 1075 400" position="1106 399" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="26" points="1161 416" /> <Input id="1854" points="1148 382" /> </Inputs> <Outputs> <Output id="27" points="1061 420" /> <Output id="28" points="1047 385" /> </Outputs> <Properties> <displayName>viral dsRNA binds IFIH1:TKFC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="168909" points="1140 688, 1115 688, 1087 696" position="1115 688" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="30" points="1127 612" /> <Input id="31" points="1186 704" /> </Inputs> <Outputs> <Output id="32" /> </Outputs> <Inhibitors> <Inhibitor id="411" points="1278 896" /> <Inhibitor id="492" points="965 564" /> </Inhibitors> <Properties> <displayName>viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="918227" points="1314 713, 1337 713, 1357 715" position="1337 713" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="69" points="1297 684" /> <Input id="32" points="1087 718, 1298 737" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Properties> <displayName>Recruitment of TRAF3 to MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="91" reactomeId="918232" points="1805 714, 1832 714, 1856 714" position="1832 714" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="92" points="1806 621" /> <Input id="1983" points="2066 855, 1775 748" /> </Inputs> <Outputs> <Output id="93" /> </Outputs> <Properties> <displayName>Recruitment of IRF3,IRF7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="102" reactomeId="918229" points="1918 621, 1918 581, 1918 542" position="1918 581" lineWidth="1.0"> <Inputs> <Input id="93" points="1920 668" /> <Input id="103" stoichiometry="6" points="1978 620" /> </Inputs> <Outputs> <Output id="104" points="1918 508" /> <Output id="2433" stoichiometry="6" points="1954 543" /> <Output id="1983" points="2066 859, 1764 771, 1764 543" /> </Outputs> <Catalysts> <Catalyst id="93" points="1910 668, 1888 579" /> </Catalysts> <Properties> <displayName>Phosphorylation and release of IRF3/IRF7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="134" reactomeId="168934" points="891 692, 869 692, 838 700" position="869 692" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="135" points="908 684" /> <Input id="136" points="877 676" /> <Input id="32" points="955 702" /> </Inputs> <Outputs> <Output id="138" /> </Outputs> <Properties> <displayName>MAVS interacts with RIPK1 and FADD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="155" reactomeId="933526" points="693 653, 653 655, 640 674" position="653 655" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="138" points="730 680" /> <Input id="156" points="689 600" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> <Properties> <displayName>Recruitment of caspase-8 and -10 to FADD complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="933523" points="517 602, 437 600, 362 657" position="437 600" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="157" points="576 674" /> <Input id="156" points="633 582" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> <Properties> <displayName>Dimerzation of procaspase-8, procaspase-10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="168" reactomeId="933532" points="301 657, 298 619, 296 553" position="298 619" lineWidth="1.0"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="1850" points="416 667" /> <Output id="170" stoichiometry="2" points="296 483" /> <Output id="169" stoichiometry="2" points="348 526" /> <Output id="172" stoichiometry="2" points="373 552" /> <Output id="173" stoichiometry="2" points="221 554" /> <Output id="174" stoichiometry="2" points="241 525" /> </Outputs> <Catalysts> <Catalyst id="159" points="326 657, 338 635" /> </Catalysts> <Properties> <displayName>Processing of caspases</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="200" reactomeId="933539" points="50 741, 51 791, 99 848" position="51 791" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="171" points="94 729" /> <Input id="201" points="100 637" /> </Inputs> <Outputs> <Output id="202" /> </Outputs> <Properties> <displayName>Recruitment of IKK complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="211" reactomeId="918230" points="2048 715, 2067 715, 2102 715" position="2067 715" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="212" points="2044 696" /> <Input id="32" points="1076 749, 1191 813, 2023 818" /> </Inputs> <Outputs> <Output id="213" /> </Outputs> <Properties> <displayName>Recruitment of TRAF6/TRAF2 to MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="214" reactomeId="933537" points="2240 716, 2267 716, 2291 716" position="2267 716" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="213" points="2208 716" /> <Input id="215" points="2226 688" /> </Inputs> <Outputs> <Output id="216" /> </Outputs> <Properties> <displayName>Recruitment of TANK to TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="217" reactomeId="933527" points="2440 717, 2466 717, 2490 717" position="2466 717" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="216" points="2425 717" /> <Input id="80" points="1470 659, 1632 793, 2424 802" /> </Inputs> <Outputs> <Output id="82" points="1680 645, 2474 651" /> <Output id="218" points="2514 716" /> </Outputs> <Properties> <displayName>Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="227" reactomeId="933538" points="2761 710, 2791 709, 2816 709" position="2791 709" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="228" points="2758 690" /> <Input id="1989" points="2629 884" /> </Inputs> <Outputs> <Output id="229" /> </Outputs> <Properties> <displayName>Recruitment of IRF7 to TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="230" reactomeId="933525" points="2881 641, 2881 607, 2880 576" position="2881 607" lineWidth="1.0"> <Inputs> <Input id="231" stoichiometry="2" points="2846 641" /> <Input id="229" points="2881 669" /> </Inputs> <Outputs> <Output id="1989" points="2612 884, 2678 688" /> <Output id="2577" stoichiometry="2" points="2831 579" /> <Output id="232" points="2880 547" /> </Outputs> <Catalysts> <Catalyst id="229" points="2907 669, 2910 668, 2909 598" /> </Catalysts> <Properties> <displayName>Phosphorylation and release of IRF7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="250" reactomeId="933533" points="2818 532, 2680 532, 2562 532" position="2680 532" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="232" stoichiometry="2" /> </Inputs> <Outputs> <Output id="251" /> </Outputs> <Properties> <displayName>Dimerization of p-IRF7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="268" reactomeId="933531" points="2518 511, 2611 399, 2613 382" position="2611 399" lineWidth="1.0"> <Inputs> <Input id="251" /> </Inputs> <Outputs> <Output id="269" /> </Outputs> <Properties> <displayName>Translocation of p-IRF7:p-IRF7 to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="270" reactomeId="933536" points="2698 360, 2709 360, 2727 360" position="2709 360" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="269" points="2674 360" /> <Input id="792" points="2448 314, 2615 314" /> </Inputs> <Outputs> <Output id="273" /> </Outputs> <Properties> <displayName>p-IRF7 dimer interacts with coactivator CBP/p300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="290" reactomeId="933528" points="3026 724, 3050 725, 3081 725" position="3050 725" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="213" points="2208 730, 2330 765, 2997 765" /> <Input id="291" points="3008 699" /> </Inputs> <Outputs> <Output id="292" /> </Outputs> <Properties> <displayName>Interaction of MEKK1 with TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="301" reactomeId="933530" points="3085 626, 3121 626, 3151 626" position="3121 626" lineWidth="1.0"> <Inputs> <Input id="302" stoichiometry="4" points="3085 654" /> <Input id="305" points="3068 627" /> </Inputs> <Outputs> <Output id="303" points="3191 625" /> <Output id="304" stoichiometry="4" points="3153 663" /> </Outputs> <Catalysts> <Catalyst id="292" points="3122 695, 3121 692" /> </Catalysts> <Properties> <displayName>Activation of IKK by MEKK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="168140" points="3225 520, 3198 520, 3165 520" position="3198 520" lineWidth="1.0"> <Inputs> <Input id="307" stoichiometry="4" points="3252 488" /> <Input id="308" points="3268 533" /> </Inputs> <Outputs> <Output id="309" points="3141 542" /> <Output id="310" points="3120 518" /> <Output id="311" stoichiometry="4" points="3138 485" /> </Outputs> <Catalysts> <Catalyst id="303" points="3237 597" /> </Catalysts> <Inhibitors> <Inhibitor id="1543" points="3197 474" /> </Inhibitors> <Properties> <displayName>Active IKK Complex phosphorylates NF-kappa-B inhibitor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="328" reactomeId="936412" points="1598 149, 1655 150, 1690 150" position="1655 150" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="329" /> </Inputs> <Outputs> <Output id="330" points="1760 147" /> <Output id="331" points="1742 121" /> <Output id="332" points="1767 183" /> </Outputs> <Catalysts> <Catalyst id="333" points="1655 187" /> </Catalysts> <Properties> <displayName>RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="342" reactomeId="936380" points="3184 172, 3212 172, 3246 172" position="3212 172" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="3158 187" /> <Input id="343" points="3157 155" /> </Inputs> <Outputs> <Output id="345" /> </Outputs> <Properties> <displayName>Interaction of PIN1 with p-IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="346" reactomeId="936462" points="3273 187, 3222 201, 3163 201" position="3222 201" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="345" /> </Inputs> <Outputs> <Output id="344" /> </Outputs> <Catalysts> <Catalyst id="1513" points="3185 269" /> </Catalysts> <Inhibitors> <Inhibitor id="1499" points="3352 422" /> </Inhibitors> <Properties> <displayName>PIN1 mediated IRF3 degradation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="347" reactomeId="936378" points="1296 600, 1318 600, 1349 601" position="1318 600" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="348" points="1270 612" /> <Input id="30" points="1189 577" /> </Inputs> <Outputs> <Output id="349" /> </Outputs> <Properties> <displayName>Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="358" reactomeId="936390" points="1497 302, 1534 302, 1557 302" position="1534 302" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="359" /> </Inputs> <Outputs> <Output id="360" points="1649 302" /> <Output id="11" points="1703 486" /> </Outputs> <Catalysts> <Catalyst id="361" points="1533 230" /> </Catalysts> <Properties> <displayName>CYLD mediated deubiquitination of DDX58 (RIG-I)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="362" reactomeId="936381" points="1436 883, 1436 964, 1382 964" position="1436 964" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1538" points="1469 880" /> <Input id="70" points="1426 766" /> </Inputs> <Outputs> <Output id="363" points="1192 926" /> <Output id="1541" points="1370 984" /> </Outputs> <Catalysts> <Catalyst id="365" points="1453 990" /> </Catalysts> <Properties> <displayName>OTUD5 deubiquitinates TRAF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="390" reactomeId="936475" points="1023 931, 989 931, 963 931" position="989 931" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="391" points="1080 961" /> <Input id="363" points="1060 924" /> </Inputs> <Outputs> <Output id="32" points="1012 749" /> <Output id="392" points="904 949" /> </Outputs> <Catalysts> <Catalyst id="1539" points="989 960" /> </Catalysts> <Properties> <displayName>Negative regulation of DDX58/IFIH1 signaling by RNF216</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="409" reactomeId="936564" points="1304 835, 1283 864, 1286 896" position="1283 864" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="410" points="1360 893" /> <Input id="31" points="1217 727" /> </Inputs> <Outputs> <Output id="411" /> </Outputs> <Properties> <displayName>NLRX1 inhibits MAVS-DDX58 interaction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="443" reactomeId="936563" points="1750 410, 1779 409, 1805 409" position="1779 409" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="444" points="1730 378" /> <Input id="11" points="1717 486" /> </Inputs> <Outputs> <Output id="445" /> </Outputs> <Properties> <displayName>ISGylation of DDX58</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="470" reactomeId="937337" points="244 1006, 275 1006, 311 1006" position="275 1006" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="471" points="203 991" /> <Input id="472" points="195 1026" /> </Inputs> <Outputs> <Output id="473" /> </Outputs> <Properties> <displayName>TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="490" reactomeId="937343" points="1019 514, 1001 514, 975 514" position="1001 514" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="30" points="1056 535" /> <Input id="491" points="1029 498" /> </Inputs> <Outputs> <Output id="492" /> </Outputs> <Properties> <displayName>NLRC5 interacts with DDX58/IFIH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="524" reactomeId="990528" points="676 938, 649 938, 627 928" position="649 938" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="525" points="687 957" /> <Input id="32" points="971 749" /> </Inputs> <Outputs> <Output id="526" /> </Outputs> <Properties> <displayName>Interaction of PCBP2 with MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="527" reactomeId="990526" points="480 930, 455 929, 429 922" position="455 929" lineWidth="1.0"> <Inputs> <Input id="526" points="511 916" /> <Input id="1535" points="541 956" /> <Input id="528" points="493 958" /> </Inputs> <Outputs> <Output id="529" /> </Outputs> <Catalysts> <Catalyst id="528" points="478 963, 454 952" /> </Catalysts> <Properties> <displayName>Recruitment of ITCH and K48 ubiquitination of MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="574" reactomeId="168166" points="3052 495, 3052 339, 3052 277" position="3052 339" lineWidth="1.0"> <Inputs> <Input id="310" /> </Inputs> <Outputs> <Output id="575" /> </Outputs> <Activators> <Activator id="577" points="2958 63, 2958 338" /> </Activators> <Properties> <displayName>NF-kappa-B complex is transported from cytosol to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="634" reactomeId="1028817" points="2311 359, 2286 359, 2259 356" position="2286 359" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="635" points="2339 362" /> <Input id="792" points="2372 333" /> </Inputs> <Outputs> <Output id="637" /> </Outputs> <Inhibitors> <Inhibitor id="2638" points="2266 287" /> <Inhibitor id="2639" points="2345 288" /> </Inhibitors> <Properties> <displayName>CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="638" reactomeId="1028815" points="2138 309, 2121 302, 2091 310" position="2121 302" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="637" points="2161 323" /> <Input id="1967" points="2128 168" /> </Inputs> <Outputs> <Output id="640" /> </Outputs> <Properties> <displayName>p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="643" reactomeId="1028812" points="2128 168, 2017 159, 2020 33" position="2017 159" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1967" /> </Inputs> <Outputs> <Output id="1498" /> </Outputs> <Activators> <Activator id="640" points="1961 306, 1951 302, 1952 160" /> </Activators> <Properties> <displayName>Expression of interferon-beta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1221" reactomeId="1028821" points="1988 483, 2142 483, 2171 483" position="2142 483" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="104" stoichiometry="3" /> </Inputs> <Outputs> <Output id="1222" points="2350 485" /> <Output id="1223" points="2250 464" /> <Output id="251" points="2446 523" /> </Outputs> <Properties> <displayName>Dimerization of Phospho IRF3 or phospho IRF7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1226" reactomeId="1028816" points="2463 434, 2494 400, 2496 384" position="2494 400" lineWidth="1.0"> <Inputs> <Input id="1222" points="2412 472" /> <Input id="1223" points="2369 445" /> <Input id="251" points="2496 511" /> </Inputs> <Outputs> <Output id="635" points="2458 377" /> <Output id="1227" points="2505 351" /> <Output id="269" points="2558 371" /> </Outputs> <Properties> <displayName>Translocation of phosphorylated IRF3,IRF7 dimers into nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1273" reactomeId="1028820" points="2524 286, 2563 286, 2621 286" position="2563 286" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1227" points="2512 322" /> <Input id="792" points="2448 304" /> </Inputs> <Outputs> <Output id="1274" /> </Outputs> <Properties> <displayName>Formation of VAF (virus-activated factor) complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1462" reactomeId="1028819" points="2726 231, 2728 207, 2730 183" position="2728 207" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1463" points="2801 266" /> <Input id="1464" points="2670 233" /> </Inputs> <Outputs> <Output id="1495" /> </Outputs> <Properties> <displayName>VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1503" points="2756 661, 2753 601, 1845 602" position="2753 601" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="228" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1505" points="2045 18, 2507 21" position="2276 19" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1498" /> </Inputs> <Outputs> <Output id="1497" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1506" points="1707 486, 1553 167" position="1630 326" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="329" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1507" points="1060 449, 1101 521" position="1080 485" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="27" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1508" points="1210 529, 1189 540" position="1199 534" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1509" points="2829 547, 2746 562, 2126 560, 1968 508" position="2436 561" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="232" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1510" points="2800 339, 2822 315" position="2811 327" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="273" /> </Inputs> <Outputs> <Output id="1463" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1511" points="2756 287, 2793 288" position="2774 287" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1274" /> </Inputs> <Outputs> <Output id="1463" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="1856" points="1185 347, 1196 349" position="1190 348" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1854" /> </Inputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndMemberLink id="1971" points="2128 168, 2550 227" position="2339 197" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1967" /> </Inputs> <Outputs> <Output id="1464" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1972" reactomeId="9604499" points="2607 218, 2586 127, 2566 47" position="2586 127" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1464" /> </Inputs> <Outputs> <Output id="1497" /> </Outputs> <Activators> <Activator id="1495" points="2666 138" /> </Activators> <Properties> <displayName>Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1978" reactomeId="9705137" points="1781 933, 1812 933, 1838 921" position="1812 933" lineWidth="1.0"> <Inputs> <Input id="81" points="1699 774" /> <Input id="1981" points="1769 986" /> </Inputs> <Outputs> <Output id="1979" /> </Outputs> <Properties> <displayName>TBK1 or IKBKE forms homodimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1982" reactomeId="9705320" points="1990 944, 2017 944, 2044 944" position="2017 944" lineWidth="1.0"> <Inputs> <Input id="2321" points="1971 958" /> <Input id="1979" points="1978 935" /> </Inputs> <Outputs> <Output id="1983" points="2070 928" /> <Output id="2324" points="2068 958" /> </Outputs> <Catalysts> <Catalyst id="1979" points="1978 904, 2016 911" /> </Catalysts> <Inhibitors> <Inhibitor id="2580" points="2018 1021" /> </Inhibitors> <Properties> <displayName>TBK1, IKBKE are autophosphorylated at Ser172</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1985" reactomeId="9705145" points="2267 938, 2291 938, 2314 929" position="2291 938" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="218" points="2521 752, 2247 902" /> <Input id="1981" points="1814 1002, 2187 1000" /> </Inputs> <Outputs> <Output id="1986" /> </Outputs> <Properties> <displayName>TBK1, IKBKE form homodimers</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1988" reactomeId="9705323" points="2451 917, 2499 926, 2534 926" position="2499 926" lineWidth="1.0"> <Inputs> <Input id="1986" /> </Inputs> <Outputs> <Output id="1989" /> </Outputs> <Catalysts> <Catalyst id="1986" points="2398 942, 2402 946" /> </Catalysts> <Properties> <displayName>Phosphorylation of TBK1/IKBKE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1991" reactomeId="9709842" points="3134 860, 3134 836, 3159 807" position="3134 836" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1992" points="3157 889" /> <Input id="1997" points="3102 888" /> </Inputs> <Outputs> <Output id="1993" /> </Outputs> <Properties> <displayName>MAVS binds TOMM70</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1998" reactomeId="9709831" points="3029 957, 3011 957, 2987 956" position="3011 957" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1999" points="3116 977" /> <Input id="2000" points="3085 952" /> <Input id="2001" points="3045 970" /> </Inputs> <Outputs> <Output id="2002" /> </Outputs> <Properties> <displayName>HSP90 binds TBK1 and IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2004" reactomeId="9709852" points="2897 927, 2874 927, 2844 920" position="2874 927" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2002" points="2914 940" /> <Input id="1993" points="3144 807" /> </Inputs> <Outputs> <Output id="2005" /> </Outputs> <Inhibitors> <Inhibitor id="2581" points="2857 1014, 2858 936" /> </Inhibitors> <Properties> <displayName>MAVS:TOMM70 recruits HSP90:TBK1:IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2586" interactionType="Activate" points="2575 1034, 2086 1034" position="2330 1034" lineWidth="2.0"> <Inputs> <Input id="2583" /> </Inputs> <Outputs> <Output id="2580" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2588" interactionType="Activate" points="2706 1032, 2813 1029" position="2759 1030" lineWidth="2.0"> <Inputs> <Input id="2583" /> </Inputs> <Outputs> <Output id="2581" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2605" reactomeId="918225" points="1524 675, 1552 675, 1578 676" position="1552 675" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="70" points="1489 693" /> <Input id="80" points="1481 659" /> </Inputs> <Outputs> <Output id="82" points="1633 653" /> <Output id="81" points="1614 697" /> </Outputs> <Inhibitors> <Inhibitor id="2606" points="1551 653" /> </Inhibitors> <Properties> <displayName>TBK1/IKK epsilon complex interacts with MAVS bound TRAF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2627" reactomeId="918224" points="1386 489, 1351 493, 1324 493" position="1351 493" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="12" points="1396 490" /> <Input id="15" stoichiometry="2" points="1411 530" /> <Input id="16" stoichiometry="2" points="1418 451" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Catalysts> <Catalyst id="16" points="1384 451, 1383 445" /> </Catalysts> <Inhibitors> <Inhibitor id="2628" points="1336 533" /> </Inhibitors> <Properties> <displayName>DDX58 is K63 polyubiquitinated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2632" interactionType="Activate" points="1586 615, 1568 624" position="1577 619" lineWidth="2.0"> <Inputs> <Input id="2630" /> </Inputs> <Outputs> <Output id="2606" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2634" interactionType="Activate" points="1554 583, 1361 568, 1347 562" position="1361 568" lineWidth="2.0"> <Inputs> <Input id="2630" /> </Inputs> <Outputs> <Output id="2628" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2640" interactionType="Activate" points="1856 277, 1866 248, 2227 251, 2243 258" position="2046 249" lineWidth="2.0"> <Inputs> <Input id="2635" /> </Inputs> <Outputs> <Output id="2638" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2641" interactionType="Activate" points="1851 277, 1857 241, 2296 246, 2329 259" position="2076 243" lineWidth="2.0"> <Inputs> <Input id="2635" /> </Inputs> <Outputs> <Output id="2639" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of DDX58/IFIH1-mediated induction of interferon-alpha/beta (992776)
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