Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q5VN06 CLF
| Class:Id | ReferenceGeneProduct:9927727 |
|---|---|
| _chainChangeLog | chain:1-896 for 9927727 added on Fri Feb 21 2025 |
| _displayName | UniProt:Q5VN06 CLF |
| _timestamp | 2025-02-21 19:57:39 |
| chain | chain:1-896 |
| checksum | 7DCE38E04E7505DF |
| comment | FUNCTION Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (Probable). Involved in the regulation of flowering. Represses flowering under long day (LD) conditions. Regulates the trimethylation on histone H3 'Lys-27' (H3K27me3) of the flowering regulators MADS14, MADS15, RFT1, EHD1, HD3A and LF (PubMed:25400654).CATALYTIC ACTIVITY L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)SUBUNIT Interacts with FIE1 (PubMed:23150632). Component of the polycomb repressive complex 2 (PRC2), composed of the core PRC2 components FIE2, EMF2B and EZ1. PRC2 methylates 'Lys-27' residues of histone H3 (H3K27me3), leading to transcriptional repression of the affected target gene (PubMed:23505380).TISSUE SPECIFICITY Widely expressed (PubMed:19825651). Highly expressed in young panicle (PubMed:23762371).MISCELLANEOUS Over-expression and down-regulation of CLF respectively, represses and promotes flowering in long day (LD), but has no effect in short day (SD).SIMILARITY Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. |
| created | [InstanceEdit:9927753] Gupta, Parul, 2024-11-08 |
| description | recommendedName: fullName evidence="13"Histone-lysine N-methyltransferase CLF shortName evidence="10"OsCLF ecNumber evidence="2"2.1.1.356 alternativeName: fullName evidence="13"Protein SET DOMAIN GROUP 711 alternativeName: fullName evidence="13"SET family protein 24 shortName evidence="11"OsSET24 |
| geneName | CLF SDG711 Os06g0275500 LOC_Os06g16390 P0038C05.29 P0676F10.40 |
| identifier | Q5VN06 |
| isSequenceChanged | FALSE |
| keyword | Chromatin regulator Developmental protein Differentiation Flowering Methyltransferase Reference proteome S-adenosyl-L-methionine Transcription Transcription regulation Transferase |
| modified | [InstanceEdit:9927861] Gupta, Parul, 2024-11-08 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CLF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CLF_ORYSJ |
| sequenceLength | 896 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:9927820] SDG711 [nucleoplasm] [Oryza sativa] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5VN06 CLF (9927727)
