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Details on Person UniProt:P23847 dppA
| Class:Id | ReferenceGeneProduct:9927601 |
|---|---|
| _chainChangeLog | signal peptide:1-28 for 9927601 added on Fri Feb 21 2025;chain:29-535 for 9927601 added on Fri Feb 21 2025 |
| _displayName | UniProt:P23847 dppA |
| _timestamp | 2025-02-21 18:55:58 |
| chain | signal peptide:1-28 chain:29-535 |
| checksum | 3F7C4756EEA8C2F0 |
| comment | FUNCTION Part of the ABC transporter DppABCDF involved in dipeptide transport (PubMed:10537211, PubMed:1702779, PubMed:7536291). Binds dipeptides and accepts a wide range of side chains, including small neutral, bulky hydrophobic, and positively and negatively charged groups (PubMed:10537211). Tripeptides are poor substrates (PubMed:10537211). DppA alone controls the specificity of the Dpp transporter (PubMed:10537211). In addition, plays a role in chemotaxis toward peptides via interaction with the chemotaxis protein Tap (PubMed:3520334, PubMed:8563629).FUNCTION Binds heme. When a foreign outer membrane heme receptor is expressed in E.coli, DppABCDF can also transport heme and its precursor, 5-aminolevulinic acid (ALA), from the periplasm into the cytoplasm.ACTIVITY REGULATION Heme binding is inhibited by dipeptide.SUBUNIT The complex is composed of two ATP-binding proteins (DppD and DppF), two transmembrane proteins (DppB and DppC) and a solute-binding protein (DppA).SUBCELLULAR LOCATION Expression is repressed by the presence of casamino acids.DOMAIN Consists of two distinct domains (I and II) connected by two strands that presumably function as a hinge (PubMed:8527431, PubMed:8563629). Undergoes conformational change upon substrate binding (PubMed:10537211).DISRUPTION PHENOTYPE Inactivation of the gene results in the inability of a proline auxotroph to utilize Pro-Gly as a proline source (PubMed:1702779). Inactivation of the gene has no effect on iron-heme utilization, but the double mppA dppA mutant is unable to use heme as iron source (PubMed:16905647).SIMILARITY Belongs to the bacterial solute-binding protein 5 family. |
| created | [InstanceEdit:9927596] Stephan, Ralf, 2024-11-08 |
| description | recommendedName: fullName evidence="13 14"Dipeptide-binding protein shortName evidence="14"DBP alternativeName: fullName evidence="13"Periplasmic dipeptide transport protein |
| geneName | dppA b3544 JW3513 |
| identifier | P23847 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chemotaxis Direct protein sequencing Disulfide bond Peptide transport Periplasm Protein transport Reference proteome Signal Transport |
| modified | [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | dppA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DPPA_ECOLI Q2M7K6 |
| sequenceLength | 535 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9927592] DppA [periplasmic space] [Escherichia coli] |
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No pathways have been reviewed or authored by UniProt:P23847 dppA (9927601)
