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Details on Person Hbp(53-1100) cleaves hemoglobin

Class:IdBlackBoxEvent:9927009
_displayNameHbp(53-1100) cleaves hemoglobin
_doReleaseTRUE
_timestamp2025-05-26 18:20:02
authored[InstanceEdit:9933028] Stephan, Ralf, 2024-12-22
catalystActivity[CatalystActivity:9927052] serine-type endopeptidase activity of Hbp(53-1100) [extracellular region]
compartment[Compartment:984] extracellular region
created[InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
goBiologicalProcess[GO_BiologicalProcess:4166] proteolysis
input[SimpleEntity:109276] H2O [extracellular region]
[Complex:9927000] HbA [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:9926999] Hbp(53-1100) [extracellular region] [Escherichia coli]
internalReviewed[InstanceEdit:9917579] Gillespie, Marc E, 2024-08-08
isChimericFALSE
literatureReference[LiteratureReference:9926930] Phylogenetic Classification and Functional Review of Autotransporters
[LiteratureReference:9926979] Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1
[LiteratureReference:9927059] Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis
[LiteratureReference:9926937] Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli
modified[InstanceEdit:9927223] Stephan, Ralf, 2024-11-05
[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
[InstanceEdit:9949829] Matthews, Lisa, 2025-05-26
[InstanceEdit:9954029] Matthews, Lisa, 2025-06-04
nameHbp(53-1100) cleaves hemoglobin
output[OtherEntity:9927045] Hemoglobin alpha fragments [extracellular region]
[OtherEntity:9926993] Hemoglobin beta fragments [extracellular region]
[SimpleEntity:917877] heme [extracellular region]
[SimpleEntity:917877] heme [extracellular region]
[Complex:9926960] Hbp(53-1100):2xheme [extracellular region] [Escherichia coli]
precedingEvent
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9949857] R-HSA-9927009.2
summation[Summation:9927215] E.coli serine protease Hbp cleaves hemoglobin (HbA) subunits...
(hasEvent)[Pathway:9927020] Heme assimilation [Homo sapiens]
(precedingEvent)[Reaction:9927224] ChuA imports heme to periplasm [Homo sapiens]
[Reaction:9927481] HmA imports heme to periplasm [Homo sapiens]
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No pathways have been reviewed or authored by Hbp(53-1100) cleaves hemoglobin (9927009)
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