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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Hbp cis-autocleaves

Class:IdReaction:9926963
_displayNameHbp cis-autocleaves
_doReleaseTRUE
_timestamp2025-11-10 17:08:53
authored[InstanceEdit:9926160] Stephan, Ralf, 2024-10-31
catalystActivity[CatalystActivity:9926992] serine-type endopeptidase activity of Hbp [cell outer membrane]
compartment[Compartment:20798] cell outer membrane
created[InstanceEdit:9927056] Stephan, Ralf, 2024-11-04
crossReference[DatabaseIdentifier:9961777] UniProt:Q9EZE7
[DatabaseIdentifier:9961778] UniProt:Q8FDW4
[DatabaseIdentifier:9961774] UniProt:Q7BSW5
[DatabaseIdentifier:9961773] UniProt:Q7BS42
[DatabaseIdentifier:9961775] UniProt:Q9XD84
disease[Disease:3134792] bacterial infectious disease
edited[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input[SimpleEntity:9926997] H2O [periplasmic space]
[EntityWithAccessionedSequence:9926950] Hbp [cell outer membrane] [Escherichia coli]
internalReviewed[InstanceEdit:9931255] Matthews, Lisa, 2024-12-11
[InstanceEdit:9937184] Matthews, Lisa, 2025-01-30
[InstanceEdit:9962261] Matthews, Lisa, 2025-08-02
isChimericFALSE
literatureReference[LiteratureReference:9927036] Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence
[LiteratureReference:9926979] Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1
[LiteratureReference:9927032] EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC), displays protease activity on human hemoglobin
[LiteratureReference:9927019] Serine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream
[LiteratureReference:9926930] Phylogenetic Classification and Functional Review of Autotransporters
modified[InstanceEdit:9931098] Stephan, Ralf, 2024-12-10
[InstanceEdit:9933047] Stephan, Ralf, 2024-12-23
[InstanceEdit:9937183] Stephan, Ralf, 2025-01-30
[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
[InstanceEdit:9949829] Matthews, Lisa, 2025-05-26
[InstanceEdit:9961779] Stephan, Ralf, 2025-07-26
[InstanceEdit:9962262] Stephan, Ralf, 2025-08-02
[InstanceEdit:9971593] D'Eustachio, Peter, 2025-11-07
[InstanceEdit:9971731] Matthews, Lisa, 2025-11-10
nameHbp cis-autocleaves
output[EntityWithAccessionedSequence:9926999] Hbp(53-1100) [extracellular region] [Escherichia coli]
[EntityWithAccessionedSequence:9927035] Hbp(1101-1377) [cell outer membrane] [Escherichia coli]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:159879] Escherichia coli
releaseDate2025-06-18
reviewed[InstanceEdit:9971594] D'Eustachio, Peter, 2025-11-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9949860] R-HSA-9926963.3
structureModified[InstanceEdit:9961779] Stephan, Ralf, 2025-07-26
summation[Summation:9926931] Serine protease autotransporters of Enterobacteriaceae (SPAT...
(hasEvent)[Pathway:9760173] Secretion of toxins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9926936] EspC(54-1018) cleaves hemoglobin [Homo sapiens]
[BlackBoxEvent:9927009] Hbp(53-1100) cleaves hemoglobin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964640] Update Tracker - [Reaction:9926963] Hbp cis-autocleaves - v94:[add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by Hbp cis-autocleaves (9926963)
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