Query author contributions in Reactome
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Details on Person ITGA2 encodes integrin alpha-2, an integrin receptor that di...
| Class:Id | Summation:9926811 |
|---|---|
| _displayName | ITGA2 encodes integrin alpha-2, an integrin receptor that di... |
| _timestamp | 2024-11-06 20:30:01 |
| created | [InstanceEdit:9926812] Rothfels, Karen, 2024-11-04 |
| modified | [InstanceEdit:9927491] Rothfels, Karen, 2024-11-06 |
| text | ITGA2 encodes integrin alpha-2, an integrin receptor that dimerizes with ITGB1 (integrin beta-1) to bind laminin, collagen, fibronectin and E-cadherin in the extracellular matrix (Emsley et al, 2000; Emsley et al, 2004; Tiger et al, 2001; reviewed in Campbell and Humphries, 2011; Pang et al, 2023). MITF-M binds to the ITGA2 gene to repress its expression in melanoma cells as assessed by MITF-M knockdown, ChIP-seq, microarray and CUT-and-RUN analysis (Dilshat et al, 2021; Webster et al, 2014; Laurette et al, 2015). MITF-M represses the expression of genes involved in extracellular matrix organization, focal adhesions and epithelial-to-mesenchymal transitions to impact the invasive/proliferative phenotype of the cell. Low levels of MITF-M are associated with a quiescent/invasive phenotype, while higher levels of MITF-M support proliferative growth (Dilshat et al, 2021; Carreira et al, 2006; Hoek et al, 2008; reviewed in Rambow et al, 2019). |
| (summation) | [BlackBoxEvent:9926533] MITF-M-dependent ITGA2 gene expression [Homo sapiens] |
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