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Details on Person MITF-M binds CREBBP,EP300

Class:IdReaction:9926478
_displayNameMITF-M binds CREBBP,EP300
_doReleaseTRUE
_timestamp2024-11-08 15:54:55
authored[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9926473] Rothfels, Karen, 2024-11-01
edited[InstanceEdit:9927257] Rothfels, Karen, 2024-11-05
input[EntityWithAccessionedSequence:9824664] MITF-M [nucleoplasm] [Homo sapiens]
[DefinedSet:1027362] CREBBP,EP300 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9927489] Orlic-Milacic, Marija, 2024-11-06
isChimericFALSE
literatureReference[LiteratureReference:9824925] CBP/p300 as a co-factor for the Microphthalmia transcription factor
[LiteratureReference:9926285] The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300
[LiteratureReference:9926257] Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor
[LiteratureReference:9824931] Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia
[LiteratureReference:9824946] c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
modified[InstanceEdit:9927255] Rothfels, Karen, 2024-11-05
[InstanceEdit:9927258] Rothfels, Karen, 2024-11-05
[InstanceEdit:9927491] Rothfels, Karen, 2024-11-06
[InstanceEdit:9927680] Rothfels, Karen, 2024-11-08
nameMITF-M binds CREBBP,EP300
output[Complex:9926393] MITF-M:CREBBP,EP300 [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2024-12-04
reviewed[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9926502] R-HSA-9926478.1
summation[Summation:9926305] MITF-M interacts with CREBBP and EP300 to activate expressio...
(hasEvent)[Pathway:9856649] Transcriptional and post-translational regulation of MITF-M expression and activity [Homo sapiens]
(precedingEvent)[Reaction:9926482] CREBBP, EP300 acetylate MITF-M [Homo sapiens]
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