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Details on Person UBE2I sumoylates MITF-M

Class:IdReaction:9926476
_displayNameUBE2I sumoylates MITF-M
_doReleaseTRUE
_timestamp2024-11-08 15:58:51
authored[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
catalystActivity[CatalystActivity:2997650] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9926432] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm] Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9926473] Rothfels, Karen, 2024-11-01
edited[InstanceEdit:9927257] Rothfels, Karen, 2024-11-05
input[EntityWithAccessionedSequence:9824664] MITF-M [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9927489] Orlic-Milacic, Marija, 2024-11-06
isChimericFALSE
literatureReference[LiteratureReference:9926234] Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
[LiteratureReference:3232149] Sumoylation of MITF and its related family members TFE3 and TFEB
modified[InstanceEdit:9927255] Rothfels, Karen, 2024-11-05
[InstanceEdit:9927258] Rothfels, Karen, 2024-11-05
[InstanceEdit:9927491] Rothfels, Karen, 2024-11-06
[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
nameUBE2I sumoylates MITF-M
output[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9926335] monoSUMO1-K182,318 MITF-M [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2024-12-04
reviewed[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9926512] R-HSA-9926476.1
summation[Summation:9926320] MITF-M is sumoylated at residues 182 and 316 (Miller et al, ...
(hasEvent)[Pathway:9856649] Transcriptional and post-translational regulation of MITF-M expression and activity [Homo sapiens]
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No pathways have been reviewed or authored by UBE2I sumoylates MITF-M (9926476)