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Details on Person MITF-M is acteylated on lysine 206 by CREBBP or EP300. Acety...
| Class:Id | Summation:9926304 |
|---|---|
| _displayName | MITF-M is acteylated on lysine 206 by CREBBP or EP300. Acety... |
| _timestamp | 2024-11-01 00:31:06 |
| created | [InstanceEdit:9926318] Rothfels, Karen, 2024-11-01 |
| text | MITF-M is acteylated on lysine 206 by CREBBP or EP300. Acetylation decreases the DNA-binding affinity at MITF-M target sites genome-wide, with a more pronounced decrease at differentiation-specific CATGTG motifs relative to canonical CACGTG elements. In this way, acetylation may contribute to the regulation of differentiation by titrating MITF-M away from differentiation-specific target genes (Louphrasitthiphol et al, 2023). MAPK-dependent phosphorylation of MITF has been shown to promote the recruitment of CREBBP/EP300 (Price et al, 1998). In a study unrelated to MITF, MAPK signaling was shown to promote the phosphorylation of CREBBP/EP300, increasing its histone acetyltransferase activity (Chen et al, 2007). These studies suggest a possible link between proliferative MAPK signaling and a decrease in MITF-dependent differentiation-specific gene expression. Consistent with this, the acetylation mimetic mutation K206Q has been identified in families with Waardenburg syndrome Type 2, displaying defects in pigmentation and hearing (Leger et al, 2012). |
| (summation) | [Reaction:9926482] CREBBP, EP300 acetylate MITF-M [Homo sapiens] |
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No pathways have been reviewed or authored by MITF-M is acteylated on lysine 206 by CREBBP or EP300. Acety... (9926304)
