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Details on Person UniProt:P08716 hlyB
| Class:Id | ReferenceGeneProduct:9926032 |
|---|---|
| _chainChangeLog | chain:1-707 for 9926032 added on Sun Nov 03 2024 |
| _displayName | UniProt:P08716 hlyB |
| _timestamp | 2024-11-03 20:14:43 |
| chain | chain:1-707 |
| checksum | 412A3EB64A3CFFBA |
| comment | FUNCTION Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.SUBUNIT Homodimer.SUBCELLULAR LOCATION In HlyB the peptidase C39 domain, the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.MISCELLANEOUS The complex HlyBD-TolC (OMF) forms a single transport channel across the two membranes, allowing direct export of alpha-hemolysin. This channel is involved in type 1 secretion system.SIMILARITY Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.CAUTION Tyr-9 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus this protein is presumed to be without peptidase activity. |
| created | [InstanceEdit:9926031] Stephan, Ralf, 2024-10-30 |
| description | recommendedName: Alpha-hemolysin translocation ATP-binding protein HlyB |
| geneName | hlyB |
| identifier | P08716 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell inner membrane Cell membrane Hydrolase Membrane Nucleotide-binding Plasmid Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | hlyB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HLYBP_ECOLX |
| sequenceLength | 707 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9926029] HlyB [plasma membrane] [Escherichia coli] |
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No pathways have been reviewed or authored by UniProt:P08716 hlyB (9926032)
