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Details on Person UniProt:P09983 hlyA
| Class:Id | ReferenceGeneProduct:9926027 |
|---|---|
| _chainChangeLog | chain:1-1023 for 9926027 added on Sun Nov 03 2024 |
| _displayName | UniProt:P09983 hlyA |
| _timestamp | 2024-11-03 19:41:16 |
| chain | chain:1-1023 |
| checksum | 196D5C0A9A28B54D |
| comment | FUNCTION Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by forming a pore.SUBCELLULAR LOCATION The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity.DOMAIN The three transmembrane domains are involved in pore formation by the cytotoxin.PTM Myristoylated by HlyC; the toxin only becomes active when modified (PubMed:12598051, PubMed:7801126). Mainly myristoylated, while a minor fraction is acylated with pentadecanoyl (C15:0; 26%) and heptadecanoyl (C17:0; 6%) fatty acyl groups (By similarity). Fatty acylation is involved in binding to host membranes and promotes the irreversible insertion of Hemolysin into the host cell membrane (PubMed:12598051). Can be activated by both myristoylation and palmitoylation, but HlyC catalyzes lysine myristoylation (PubMed:32461253).MISCELLANEOUS The hemolysin of E.coli is produced predominantly by strains causing extraintestinal infections, such as those of the urinary tract.SIMILARITY Belongs to the RTX prokaryotic toxin (TC 1.C.11) family. |
| created | [InstanceEdit:9926031] Stephan, Ralf, 2024-10-30 |
| description | recommendedName: fullName evidence="11"Hemolysin, chromosomal |
| geneName | hlyA |
| identifier | P09983 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cytolysis Direct protein sequencing Hemolysis Host cell membrane Host membrane Lipoprotein Membrane Myristate Repeat Secreted Toxin Transmembrane Transmembrane helix Virulence |
| modified | [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | hlyA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HLYAC_ECOLX |
| sequenceLength | 1023 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9926033] HlyA [periplasmic space] [Escherichia coli] [EntityWithAccessionedSequence:9926040] HlyA [extracellular region] [Escherichia coli] [EntityWithAccessionedSequence:9926042] HlyA [cytosol] [Escherichia coli] |
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No pathways have been reviewed or authored by UniProt:P09983 hlyA (9926027)
