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Details on Person HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space

Class:Id	Reaction:9926021
_displayName	HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space
_doRelease	TRUE
_timestamp	2025-05-21 07:42:59
authored	[InstanceEdit:9926023] Stephan, Ralf, 2024-10-30
catalystActivity	[CatalystActivity:9926034] porin activity of HlyB:HlyD:TolC [cell outer membrane]
compartment	[Compartment:1222638] periplasmic space [Compartment:20798] cell outer membrane [Compartment:984] extracellular region
created	[InstanceEdit:9926031] Stephan, Ralf, 2024-10-30
disease	[Disease:3134792] bacterial infectious disease
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
input	[DefinedSet:9926028] HlyA [periplasmic space] [Escherichia coli]
internalReviewed	[InstanceEdit:9937184] Matthews, Lisa, 2025-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9926096] Nucleotide sequence of an Escherichia coli chromosomal hemolysin [LiteratureReference:9926097] HlyB-dependent secretion of hemolysin by uropathogenic Escherichia coli requires conserved sequences flanking the chromosomal hly determinant [LiteratureReference:9926098] Effects of Escherichia coli hemolysin on endothelial cell function [LiteratureReference:9926114] Enterobacterial hemolysins: activation, secretion and pore formation [LiteratureReference:9926093] In vivo and in vitro studies on interactions between the components of the hemolysin (HlyA) secretion machinery of Escherichia coli [LiteratureReference:9911195] Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
modified	[InstanceEdit:9926107] Stephan, Ralf, 2024-10-31 [InstanceEdit:9931098] Stephan, Ralf, 2024-12-10 [InstanceEdit:9933047] Stephan, Ralf, 2024-12-23 [InstanceEdit:9937183] Stephan, Ralf, 2025-01-30 [InstanceEdit:9939561] Stephan, Ralf, 2025-02-28 [InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space
output	[DefinedSet:9926037] HlyA [extracellular region] [Escherichia coli]
precedingEvent	[Reaction:9926041] HlyB:HlyD:TolC transports HlyA from cytosol to periplasm [Homo sapiens]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9926046] R-HSA-9926021.1
summation	[Summation:9926112] E. coli strains causing extraintestinal infections secrete α...
(hasEvent)	[Pathway:9760173] Secretion of toxins [Homo sapiens]
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No pathways have been reviewed or authored by HlyB:HlyD:TolC transports HlyA from periplasm to extracellular space (9926021)