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Details on Person CD274 mRNA binds miR-Let7-a1 RISC

Class:Id	Reaction:9925246
_displayName	CD274 mRNA binds miR-Let7-a1 RISC
_doRelease	TRUE
_timestamp	2025-08-26 07:56:46
authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927358] Tiwari, Krishna, 2024-11-05
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9925315] Tiwari, Krishna, 2024-10-16
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
input	[CandidateSet:9860164] miR-Let7-a1 RISC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9909617] CD274 mRNA [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9929194] D'Eustachio, Peter, 2024-10-18
isChimeric	FALSE
literatureReference	[LiteratureReference:9924884] Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC) [LiteratureReference:9925103] LIN28/let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy
modified	[InstanceEdit:9925426] Tiwari, Krishna, 2024-10-16 [InstanceEdit:9929193] Tiwari, Krishna, 2024-11-21 [InstanceEdit:9963582] Gillespie, Marc E, 2025-08-14 [InstanceEdit:9964108] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964110] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964120] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964121] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9964125] Gillespie, Marc E, 2025-08-19 [InstanceEdit:9965199] Matthews, Lisa, 2025-08-26
name	CD274 mRNA binds miR-Let7-a1 RISC
output	[Complex:9925209] CD274 mRNA:miR-let7-a1 RISC [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9909623] CD274 Transcription [Homo sapiens] [Reaction:9909610] AP-1 binding to CD274 gene [Homo sapiens] [Reaction:9909594] ATF3 binding to CD274 gene [Homo sapiens] [Reaction:9909635] BRD4 binding to CD274 gene chromatin [Homo sapiens] [Reaction:9909632] CTNNB1 binding to CD274 gene [Homo sapiens] [Reaction:9909618] HIF1A,EPAS1 binding to CD274 gene [Homo sapiens] [Reaction:9909608] IRF1 binding to CD274 promoter [Homo sapiens] [Reaction:9909602] MYC,MYCN binding to CD274 gene [Homo sapiens] [Reaction:9909622] NFKB_complex binding to CD274 gene [Homo sapiens] [Reaction:9909652] NFE2L2 binding to CD274 gene [Homo sapiens] [Reaction:9909657] STAT1 dimer binding to CD274 gene [Homo sapiens] [Reaction:9909609] STAT3 dimer binding to CD274 gene [Homo sapiens] [Reaction:9909654] YAP1/TAZ binding to CD274 gene [Homo sapiens] [Reaction:9909628] Trimethylation of CD274 gene chromatin by MLL1/3 complex [Homo sapiens] [Reaction:9909631] Trimethylation of CD274 gene promoter by EZH2 [Homo sapiens]
releaseDate	2025-09-18
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9925412] R-HSA-9925246.1
summation	[Summation:9924982] MicroRNA-Let7a (miR-Let7a) is expressed in a wide variety of...
(hasEvent)	[Pathway:9909620] Regulation of PD-L1(CD274) translation [Homo sapiens]
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No pathways have been reviewed or authored by CD274 mRNA binds miR-Let7-a1 RISC (9925246)