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Details on Person MicroRNA-424 (miR-424) expression, regulated by hypoxia and ...

Class:IdSummation:9925108
_displayNameMicroRNA-424 (miR-424) expression, regulated by hypoxia and ...
_timestamp2024-10-29 11:59:47
created[InstanceEdit:9925315] Tiwari, Krishna, 2024-10-16
literatureReference[LiteratureReference:9925257] Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
[LiteratureReference:9925254] The unique expression and function of miR-424 in human placental trophoblasts
[LiteratureReference:9924842] Role of miR-424 in the carcinogenesis
[LiteratureReference:9924847] miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
[LiteratureReference:9925129] LINC00657 knockdown suppresses hepatocellular carcinoma progression by sponging miR-424 to regulate PD-L1 expression
modified[InstanceEdit:9925426] Tiwari, Krishna, 2024-10-16
[InstanceEdit:9925973] Tiwari, Krishna, 2024-10-29
textMicroRNA-424 (miR-424) expression, regulated by hypoxia and hypoxia induced expression, is observed in human endothelial cells and placental trophoblast (Ghosh et al., 2010, Mouillet et al., 2013). It is downregulated in cancers and its high expression is related to reversal of chemoresistance via activation of T-cell immune response (Xu et al., 2016, Ghafouri-Fard et al., 2024). miR-424 also plays a role in the regulation of CD274 (PD-L1) expression. miR-424 bind the 3' UTR region of PDL1 mRNA and suppress its expression by inhibiting PDL1 translation (Xu et al., 2016, Cao et al., 2020).
(summation)[Reaction:9925289] CD274 mRNA binds miR-424 RISC [Homo sapiens]
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