Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NS3 cleaves triphosphate moiety of genomic +ssRNA

Class:IdReaction:9923980
_displayNameNS3 cleaves triphosphate moiety of genomic +ssRNA
_doReleaseTRUE
_timestamp2026-03-03 08:56:05
authored[InstanceEdit:9923961] Stephan, Ralf, 2024-10-05
catalystActivity[CatalystActivity:9923984] polynucleotide 5'-phosphatase activity of DENV nascent +ssRNA:RC [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9923982] Stephan, Ralf, 2024-10-06
crossReference[DatabaseIdentifier:9923978] RHEA:67005
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input[SimpleEntity:29356] H2O [cytosol]
[Complex:9980076] DENV nascent +ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9923971] Expression, purification, and characterization of the RNA 5'-triphosphatase activity of dengue virus type 2 nonstructural protein 3
modified[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925612] Stephan, Ralf, 2024-10-19
[InstanceEdit:9925627] Stephan, Ralf, 2024-10-20
[InstanceEdit:9925765] Stephan, Ralf, 2024-10-24
[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964207] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966339] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9980075] Stephan, Ralf, 2026-01-24
[InstanceEdit:9980081] Stephan, Ralf, 2026-01-24
[InstanceEdit:9984050] Stephan, Ralf, 2026-03-03
nameNS3 cleaves triphosphate moiety of genomic +ssRNA
output[SimpleEntity:111294] PPi [cytosol]
[Complex:9980082] DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9923987] R-HSA-9923980.2
structureModified[InstanceEdit:9925627] Stephan, Ralf, 2024-10-20
[InstanceEdit:9925765] Stephan, Ralf, 2024-10-24
[InstanceEdit:9980075] Stephan, Ralf, 2026-01-24
[InstanceEdit:9980081] Stephan, Ralf, 2026-01-24
summation[Summation:9923981] DENV NS3 protein hydrolyzes the γ-phosphate from the 5′-trip...
(hasEvent)[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9923071] NS5 transfers guanylyl onto DENV genomic 5'-ppRNA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984675] Update Tracker - [Reaction:9923980] NS3 cleaves triphosphate moiety of genomic +ssRNA - v96:[add_removeInput, add_removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by NS3 cleaves triphosphate moiety of genomic +ssRNA (9923980)
Follow Reactome