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Details on Person NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA

Class:Id	Reaction:9923097
_displayName	NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA
_doRelease	TRUE
_timestamp	2026-03-03 08:56:48
authored	[InstanceEdit:9924070] Stephan, Ralf, 2024-10-07
catalystActivity	[CatalystActivity:9923090] methyltransferase cap1 activity of DENV m7G(5')ppp-+ssRNA:RC [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9923106] Stephan, Ralf, 2024-09-30
crossReference	[DatabaseIdentifier:9923117] RHEA:67021
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input	[SimpleEntity:9639461] S-adenosyl-L-methionine [cytosol] [Complex:9980064] DENV m7G(5')ppp-+ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9691299] West Nile virus 5'-cap structure is formed by sequential guanine N-7 and ribose 2'-O methylations by nonstructural protein 5 [LiteratureReference:9923091] An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization [LiteratureReference:9925626] The flavivirus polymerase NS5 regulates translation of viral genomic RNA [LiteratureReference:9946644] Evasion of early innate immune response by 2'-O-methylation of dengue genomic RNA
modified	[InstanceEdit:9923116] Stephan, Ralf, 2024-09-30 [InstanceEdit:9923534] Stephan, Ralf, 2024-10-01 [InstanceEdit:9924075] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925612] Stephan, Ralf, 2024-10-19 [InstanceEdit:9925627] Stephan, Ralf, 2024-10-20 [InstanceEdit:9925765] Stephan, Ralf, 2024-10-24 [InstanceEdit:9946666] Stephan, Ralf, 2025-04-27 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964207] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966339] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9980063] Stephan, Ralf, 2026-01-24 [InstanceEdit:9980069] Stephan, Ralf, 2026-01-24 [InstanceEdit:9984050] Stephan, Ralf, 2026-03-03
name	NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA
output	[SimpleEntity:9639443] S-adenosyl-L-homocysteine [cytosol] [Complex:9980070] DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent	[BlackBoxEvent:9923104] NS5 acts as a cap N7 methyltransferase to methylate 5’ G pppA of DENV genomic +ssRNA [Homo sapiens] [BlackBoxEvent:9923071] NS5 transfers guanylyl onto DENV genomic 5'-ppRNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9923112] R-HSA-9923097.2
structureModified	[InstanceEdit:9923116] Stephan, Ralf, 2024-09-30 [InstanceEdit:9925627] Stephan, Ralf, 2024-10-20 [InstanceEdit:9925765] Stephan, Ralf, 2024-10-24 [InstanceEdit:9980063] Stephan, Ralf, 2026-01-24 [InstanceEdit:9980069] Stephan, Ralf, 2026-01-24
summation	[Summation:9923530] NS5 subunit of the DENV Replication Complex (RC) catalyzes 2...
(hasEvent)	[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9922957] NS3 melts (+)-RNA secondary structures [Homo sapiens] [Reaction:9923094] DENV capped genome (+)-RNA dissociates from RC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984581] Update Tracker - [Reaction:9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA - v96:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA (9923097)