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Details on Person NS3 unwinds dsRNA secondary structures

Class:IdBlackBoxEvent:9923073
_displayNameNS3 unwinds dsRNA secondary structures
_doReleaseTRUE
_timestamp2026-03-03 08:56:35
authored[InstanceEdit:9924070] Stephan, Ralf, 2024-10-07
catalystActivity[CatalystActivity:9925763] helicase activity of DENV -ssRNA genome replicate with secondary dsRNA structure:RC [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9923072] Stephan, Ralf, 2024-09-29
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess[GO_BiologicalProcess:590] RNA metabolic process
input[SimpleEntity:6806881] NTP [cytosol]
[Complex:9979951] DENV -ssRNA genome replicate with secondary dsRNA structure:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
[InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimericFALSE
literatureReference[LiteratureReference:9923524] Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A
[LiteratureReference:9919995] Molecular Insights into the Flavivirus Replication Complex
[LiteratureReference:9925579] NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
[LiteratureReference:9945291] Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase
[LiteratureReference:9920214] Structures of dengue virus RNA replicase complexes
[LiteratureReference:9946475] The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication
[LiteratureReference:9946471] Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity
[LiteratureReference:9946470] Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein
modified[InstanceEdit:9923534] Stephan, Ralf, 2024-10-01
[InstanceEdit:9924075] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925587] Stephan, Ralf, 2024-10-18
[InstanceEdit:9925765] Stephan, Ralf, 2024-10-24
[InstanceEdit:9939475] Stephan, Ralf, 2025-02-27
[InstanceEdit:9945288] Stephan, Ralf, 2025-04-13
[InstanceEdit:9946397] Stephan, Ralf, 2025-04-24
[InstanceEdit:9946476] Stephan, Ralf, 2025-04-25
[InstanceEdit:9960000] Stephan, Ralf, 2025-07-04
[InstanceEdit:9960003] Stephan, Ralf, 2025-07-04
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964207] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966301] Stephan, Ralf, 2025-09-14
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966339] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9979952] Stephan, Ralf, 2026-01-23
[InstanceEdit:9979964] Stephan, Ralf, 2026-01-23
[InstanceEdit:9984050] Stephan, Ralf, 2026-03-03
nameNS3 unwinds dsRNA secondary structures
NS3 melts dsRNA secondary structures in -ssRNA replicate
output[SimpleEntity:6806885] NDP [cytosol]
[Complex:9979963] DENV -ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9923088] R-HSA-9923073.2
structureModified[InstanceEdit:9925765] Stephan, Ralf, 2024-10-24
[InstanceEdit:9945288] Stephan, Ralf, 2025-04-13
[InstanceEdit:9979952] Stephan, Ralf, 2026-01-23
[InstanceEdit:9979964] Stephan, Ralf, 2026-01-23
summation[Summation:9923513] NS3 subunit of the DENV replication complex unwinds viral RN...
(hasEvent)[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9923074] Circularization of (-)-genomic RNA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984684] Update Tracker - [BlackBoxEvent:9923073] NS3 unwinds dsRNA secondary structures - v96:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by NS3 unwinds dsRNA secondary structures (9923073)
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