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Details on Person NS5 transfers guanylyl onto DENV genomic 5'-ppRNA

Class:IdBlackBoxEvent:9923071
_displayNameNS5 transfers guanylyl onto DENV genomic 5'-ppRNA
_doReleaseTRUE
_timestamp2026-03-03 08:57:56
authored[InstanceEdit:9922958] Stephan, Ralf, 2024-09-28
catalystActivity[CatalystActivity:9923063] mRNA guanylyltransferase activity of DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9923072] Stephan, Ralf, 2024-09-29
crossReference[DatabaseIdentifier:9923118] RHEA:67013
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input[SimpleEntity:29438] GTP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[Complex:9980082] DENV pp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9923101] The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure
modified[InstanceEdit:9923116] Stephan, Ralf, 2024-09-30
[InstanceEdit:9923534] Stephan, Ralf, 2024-10-01
[InstanceEdit:9923982] Stephan, Ralf, 2024-10-06
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925612] Stephan, Ralf, 2024-10-19
[InstanceEdit:9925627] Stephan, Ralf, 2024-10-20
[InstanceEdit:9925765] Stephan, Ralf, 2024-10-24
[InstanceEdit:9954417] Stephan, Ralf, 2025-06-07
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964208] Stephan, Ralf, 2025-08-20
[InstanceEdit:9965549] Stephan, Ralf, 2025-08-30
[InstanceEdit:9965630] Stephan, Ralf, 2025-09-03
[InstanceEdit:9966301] Stephan, Ralf, 2025-09-14
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966338] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
[InstanceEdit:9979970] Stephan, Ralf, 2026-01-23
[InstanceEdit:9980081] Stephan, Ralf, 2026-01-24
[InstanceEdit:9984050] Stephan, Ralf, 2026-03-03
nameNS5 transfers guanylyl onto DENV genomic 5'-ppRNA
output[SimpleEntity:111294] PPi [cytosol]
[Complex:9979969] DENV Gppp-5'A-+ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9923080] R-HSA-9923071.2
structureModified[InstanceEdit:9923982] Stephan, Ralf, 2024-10-06
[InstanceEdit:9925627] Stephan, Ralf, 2024-10-20
[InstanceEdit:9925765] Stephan, Ralf, 2024-10-24
[InstanceEdit:9979970] Stephan, Ralf, 2026-01-23
[InstanceEdit:9980081] Stephan, Ralf, 2026-01-24
summation[Summation:9923525] The flavivirus NS5 protein, as part of the DENV Replication ...
(hasEvent)[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9923104] NS5 acts as a cap N7 methyltransferase to methylate 5’ G pppA of DENV genomic +ssRNA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984654] Update Tracker - [BlackBoxEvent:9923071] NS5 transfers guanylyl onto DENV genomic 5'-ppRNA - v96:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by NS5 transfers guanylyl onto DENV genomic 5'-ppRNA (9923071)
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