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Details on Person p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene

Class:Id	Reaction:9923010
_displayName	p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene
_doRelease	TRUE
_timestamp	2025-02-18 21:13:39
authored	[InstanceEdit:9923004] May, Bruce, 2024-09-21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9922979] May, Bruce, 2024-09-29
edited	[InstanceEdit:9923004] May, Bruce, 2024-09-21
inferredFrom	[Reaction:9926618] p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Nr1d1 (Rev-erba) gene [Mus musculus]
input	[Complex:9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [Homo sapiens] [Complex:9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5641202] NR1D1 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1183223] KMT2A [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
modified	[InstanceEdit:9926648] May, Bruce, 2024-11-01 [InstanceEdit:9930033] May, Bruce, 2024-11-30 [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene
output	[Complex:9922981] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens] [Reaction:9912390] p-S90-BMAL1 binds p-T451,T461-CLOCK [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9923051] R-HSA-9923010.1
structureModified	[InstanceEdit:9930033] May, Bruce, 2024-11-30
summation	[Summation:9930024] Phosphorylated BMAL1:CLOCK heterodimers bind multiple E-boxe...
(hasEvent)	[Pathway:9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:549475] Expression of NR1D1 (REV-ERBA) [Homo sapiens] [BlackBoxEvent:9920724] p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 [Homo sapiens] [BlackBoxEvent:9923018] Phosphorylated BMAL1:CLOCK positively regulates expression of NR1D1 (REV-ERBA) [Homo sapiens]
(replacementInstances)	[_Deleted:9938755] Deletion of instance: 5663155
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No pathways have been reviewed or authored by p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene (9923010)