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Details on Person Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-2 (PER2)

Class:Id	BlackBoxEvent:9922990
_displayName	Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-2 (PER2)
_doRelease	TRUE
_timestamp	2025-02-18 21:07:15
authored	[InstanceEdit:9923004] May, Bruce, 2024-09-21
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9922979] May, Bruce, 2024-09-29
edited	[InstanceEdit:9923004] May, Bruce, 2024-09-21
inferredFrom	[BlackBoxEvent:9926608] Phosphorylated Bmal1:Clock,Npas2 and coactivators positively regulate expression of Per2 [Mus musculus]
input	[EntityWithAccessionedSequence:5641227] PER2 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9930029] Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
modified	[InstanceEdit:9926648] May, Bruce, 2024-11-01 [InstanceEdit:9929342] May, Bruce, 2024-11-24 [InstanceEdit:9930033] May, Bruce, 2024-11-30 [InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9933436] May, Bruce, 2024-12-30 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936399] May, Bruce, 2025-01-22 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-2 (PER2)
output	[EntityWithAccessionedSequence:400399] PER2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9922998] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER2 gene [Homo sapiens] [BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9922993] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER2 gene [nucleoplasm]'
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9923029] R-HSA-9922990.1
summation	[Summation:9929295] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimers bound ...
(hasEvent)	[Pathway:9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes [Homo sapiens]
(precedingEvent)	[Reaction:9920673] CDK5 phosphorylates PER2 on serine-396 [Homo sapiens] [Reaction:9923137] Casein kinase II (CK2, CSNK2A1,2:CSNK2B) binds PER2 [Homo sapiens]
(replacementInstances)	[_Deleted:9938724] Deletion of instance: 549493
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No pathways have been reviewed or authored by Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-2 (PER2) (9922990)