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Details on Person Phosphorylated BMAL1:CLOCK positively regulates expression of RORA

Class:Id	BlackBoxEvent:9922984
_displayName	Phosphorylated BMAL1:CLOCK positively regulates expression of RORA
_doRelease	TRUE
_timestamp	2025-02-18 21:06:48
authored	[InstanceEdit:9923004] May, Bruce, 2024-09-21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9922979] May, Bruce, 2024-09-29
edited	[InstanceEdit:9923004] May, Bruce, 2024-09-21
inferredFrom	[BlackBoxEvent:9926666] Phosphorylated Bmal1:Clock positively regulates expression of Rora [Mus musculus]
input	[EntityWithAccessionedSequence:5640202] RORA gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
modified	[InstanceEdit:9926673] May, Bruce, 2024-11-01 [InstanceEdit:9930033] May, Bruce, 2024-11-30 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Phosphorylated BMAL1:CLOCK positively regulates expression of RORA
output	[EntityWithAccessionedSequence:400325] RORA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9923006] p-S90-BMAL1:p-T451,T461-CLOCK binds the RORA gene [Homo sapiens] [BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9922985] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:RORA gene [nucleoplasm]'
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9923043] R-HSA-9922984.1
summation	[Summation:9929970] In mice, Clock is required for normal expression of the Rora...
(hasEvent)	[Pathway:9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1368106] Expression of Caveolin-3 [Homo sapiens] [Reaction:5663264] RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene [Homo sapiens] [Reaction:5663293] RORA and EP300 bind the SREBF1 (SREBP1) gene [Homo sapiens] [Reaction:9911560] RORA,B,C, EP300, PPARGC1A, NRIP1 bind BMAL1 (ARNTL) gene [Homo sapiens] [Reaction:9931531] RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene [Homo sapiens] [Reaction:9932081] RORA,C and coactivators bind the CLOCK gene [Homo sapiens]
(replacementInstances)	[_Deleted:9938766] Deletion of instance: 1368133
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No pathways have been reviewed or authored by Phosphorylated BMAL1:CLOCK positively regulates expression of RORA (9922984)