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Details on Person NS3 melts (+)-RNA secondary structures

Class:Id	BlackBoxEvent:9922957
_displayName	NS3 melts (+)-RNA secondary structures
_doRelease	TRUE
_timestamp	2026-03-03 08:56:20
authored	[InstanceEdit:9922933] Stephan, Ralf, 2024-09-27
catalystActivity	[CatalystActivity:9922956] helicase activity of DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9922958] Stephan, Ralf, 2024-09-28
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess	[GO_BiologicalProcess:590] RNA metabolic process
input	[SimpleEntity:6806881] NTP [cytosol] [Complex:9980070] DENV m7G(5')pppAm-capped genomic +ssRNA:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23 [InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric	FALSE
literatureReference	[LiteratureReference:9923524] Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A [LiteratureReference:9919995] Molecular Insights into the Flavivirus Replication Complex [LiteratureReference:9925579] NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication [LiteratureReference:9945291] Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase [LiteratureReference:9920214] Structures of dengue virus RNA replicase complexes [LiteratureReference:9946475] The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication [LiteratureReference:9946471] Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity [LiteratureReference:9946470] Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein [LiteratureReference:9954818] Identification of a Direct-Acting Antiviral Agent Targeting RNA Helicase via a Graphene Oxide Nanobiosensor [LiteratureReference:9954817] Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
modified	[InstanceEdit:9923072] Stephan, Ralf, 2024-09-29 [InstanceEdit:9923534] Stephan, Ralf, 2024-10-01 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925587] Stephan, Ralf, 2024-10-18 [InstanceEdit:9925765] Stephan, Ralf, 2024-10-24 [InstanceEdit:9939475] Stephan, Ralf, 2025-02-27 [InstanceEdit:9939564] Stephan, Ralf, 2025-02-28 [InstanceEdit:9945288] Stephan, Ralf, 2025-04-13 [InstanceEdit:9946397] Stephan, Ralf, 2025-04-24 [InstanceEdit:9946476] Stephan, Ralf, 2025-04-25 [InstanceEdit:9955740] Stephan, Ralf, 2025-06-11 [InstanceEdit:9960000] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960002] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964207] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966339] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9979957] Stephan, Ralf, 2026-01-23 [InstanceEdit:9980069] Stephan, Ralf, 2026-01-24 [InstanceEdit:9984050] Stephan, Ralf, 2026-03-03
name	NS3 melts (+)-RNA secondary structures
output	[SimpleEntity:6806885] NDP [cytosol] [Complex:9979958] DENV +ssRNA with no secondary structures:RC [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent	[Reaction:9922961] DENV genomic RNA binds Replication Complex [Homo sapiens] [BlackBoxEvent:9920087] Nonstructural proteins form the replication complex [Homo sapiens] [BlackBoxEvent:9922491] Dengue virion releases its genome [Homo sapiens] [BlackBoxEvent:9922955] NS5 synthesizes minus strand genome [Homo sapiens] [Reaction:9923094] DENV capped genome (+)-RNA dissociates from RC [Homo sapiens] [Reaction:9923097] NS5 acts as a cap 2'-O-methyltransferase to methylate 5’ m7GpppA of DENV genomic +ssRNA [Homo sapiens] [BlackBoxEvent:9923104] NS5 acts as a cap N7 methyltransferase to methylate 5’ G pppA of DENV genomic +ssRNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9955742] Negative regulation by 'Dengue helicase inhibitor [cytosol]'
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29 [InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9922968] R-HSA-9922957.2
structureModified	[InstanceEdit:9945288] Stephan, Ralf, 2025-04-13 [InstanceEdit:9955740] Stephan, Ralf, 2025-06-11 [InstanceEdit:9979957] Stephan, Ralf, 2026-01-23 [InstanceEdit:9980069] Stephan, Ralf, 2026-01-24
summation	[Summation:9923526] The NS3 subunit of the DENV replication complex unwinds vira...
(hasEvent)	[Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9922965] Circularization of (+)-genomic RNA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984700] Update Tracker - [BlackBoxEvent:9922957] NS3 melts (+)-RNA secondary structures - v96:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by NS3 melts (+)-RNA secondary structures (9922957)