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Details on Person Interferon alpha-inducible protein 6 (IFI6) has been implica...
| Class:Id | Summation:9921821 |
|---|---|
| _displayName | Interferon alpha-inducible protein 6 (IFI6) has been implica... |
| _timestamp | 2024-11-05 18:05:16 |
| created | [InstanceEdit:9921811] Shamovsky, Veronica, 2024-09-13 |
| literatureReference | [LiteratureReference:9921817] An IFI6-based hydrogel promotes the healing of radiation-induced skin injury through regulation of the HSF1 activity [LiteratureReference:9921796] Interferon-α inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells [LiteratureReference:9921793] A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication [LiteratureReference:9921803] The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein [LiteratureReference:9927393] HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum |
| modified | [InstanceEdit:9921839] Shamovsky, Veronica, 2024-09-13 [InstanceEdit:9924236] Shamovsky, Veronica, 2024-10-09 [InstanceEdit:9927388] Shamovsky, Veronica, 2024-11-05 |
| text | Interferon alpha-inducible protein 6 (IFI6) has been implicated in various cellular stress response pathways, potentially modulating the activity of proteins involved in these pathways (Richardson RB et al., 2018; Jia H et al., 2020; Hao J et al., 2022). This Reactome event shows interaction of IFI6 with endoplasmic reticulum (ER) chaperone BiP (encoded by the HSPA5 gene), which is involved in protein folding and stress management in response to microorganisms (Richardson RB et al., 2018; Shin WJ e al., 2022). HSPA5 (BiP), which is primarily located in the ER lumen, binds unfolded proteins as well as the luminal domains of ER-membrane-bound signal transducers ATF6, IRE1, and PERK (EIF2AK3) that facilitate unfolded protein response (UPR) during ER stress (Wang J et al., 2017). The interaction between IFI6 and HSPA5 is thought to interfere with virus-triggered ER membrane alterations, including invagination, preventing the formation of a specialized ER microenvironment for viral replication (Richardson RB et al., 2018). |
| (summation) | [Reaction:9921802] IFI6 binds HSPA5 [Homo sapiens] |
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No pathways have been reviewed or authored by Interferon alpha-inducible protein 6 (IFI6) has been implica... (9921821)
