Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NS3 cleaves GrpEL1

Class:IdReaction:9921689
_displayNameNS3 cleaves GrpEL1
_doReleaseTRUE
_timestamp2025-10-30 11:49:17
authored[InstanceEdit:9921622] Stephan, Ralf, 2024-09-12
catalystActivity[CatalystActivity:9921694] serine-type endopeptidase activity of NS3 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:9921690] Stephan, Ralf, 2024-09-13
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
input[EntityWithAccessionedSequence:9921697] GRPEL1 [mitochondrial matrix] [Homo sapiens]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9920581] Mitochondrial Import of Dengue Virus NS3 Protease and Cleavage of GrpEL1, a Cochaperone of Mitochondrial Hsp70
modified[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925766] Stephan, Ralf, 2024-10-24
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964207] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966339] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameNS3 cleaves GrpEL1
output[EntityWithAccessionedSequence:9921692] GRPEL1(28-80) [mitochondrial matrix] [Homo sapiens]
[EntityWithAccessionedSequence:9921722] GRPEL1(81-91) [mitochondrial matrix] [Homo sapiens]
[EntityWithAccessionedSequence:9921714] GRPEL1(92-217) [mitochondrial matrix] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9921741] R-HSA-9921689.1
summation[Summation:9921703] Mitochondrial DENV NS3 protease cleaves GrpE protein homolog...
(hasEvent)[Pathway:9918481] Dengue Virus-Host Interactions [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NS3 cleaves GrpEL1 (9921689)