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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person NS1 binds TLR4

Class:IdReaction:9921458
_displayNameNS1 binds TLR4
_doReleaseTRUE
_timestamp2025-10-30 11:45:28
authored[InstanceEdit:9921340] Stephan, Ralf, 2024-09-09
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9921459] Stephan, Ralf, 2024-09-10
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
input[Complex:9920090] NS1 hexamer lipoparticle [plasma membrane] [Dengue virus type 2]
[Complex:166050] TLR4:LY96 [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9921480] Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity
[LiteratureReference:9921478] Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6
[LiteratureReference:9921462] Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
modified[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925766] Stephan, Ralf, 2024-10-24
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964205] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966337] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameNS1 binds TLR4
output[Complex:9921476] TLR4:LY96:NS1 [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9921497] R-HSA-9921458.1
summation[Summation:9921465] Secreted Dengue virus (DENV) NS1 protein, primarily from DEN...
(hasEvent)[Pathway:9918481] Dengue Virus-Host Interactions [Homo sapiens]
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No pathways have been reviewed or authored by NS1 binds TLR4 (9921458)