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Details on Person Upon clot formation, fibrin multimers bind activated αIIbβ3 ...
| Class:Id | Summation:9921092 |
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| _displayName | Upon clot formation, fibrin multimers bind activated αIIbβ3 ... |
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| _timestamp | 2025-01-12 05:14:29 |
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| created | [InstanceEdit:9921099] Shamovsky, Veronica, 2024-09-05 |
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| literatureReference | [LiteratureReference:9921068] Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor
[LiteratureReference:9921065] Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen
[LiteratureReference:9921038] Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII
[LiteratureReference:9921084] Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi
[LiteratureReference:9921030] The Platelet Integrin αIIbβ3 Differentially Interacts with Fibrin Versus Fibrinogen
[LiteratureReference:9921036] The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain
[LiteratureReference:9921062] αIIbβ3 binding to a fibrinogen fragment lacking the γ-chain dodecapeptide is activation dependent and EDTA inducible
[LiteratureReference:9921023] Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation
[LiteratureReference:9921072] The relative importance of platelet integrins in hemostasis, thrombosis and beyond |
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| modified | [InstanceEdit:9935057] Shamovsky, Veronica, 2025-01-12 |
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| text | Upon clot formation, fibrin multimers bind activated αIIbβ3 (ITGA2B:ITGB3) on the surface of activated platelets. This interaction influences the stability and architecture of the forming clot (Savage B et al., 1992; Podolnikova NP et al., 2014; Zafar H et al., 2017; Litvinov RI et al., 2016; Höök P et al., 2017; Zhang Y et al., 2018; reviewed by Janus‑Bell E & Mangin PH 2023). Additionally, fibrin and activated αIIbβ3 (ITGA2B:ITGB3) promote association of phosphatidylserine (PS)‑bearing activated platelets with factor XIII (FXIII), a transglutaminase, which further stabilizes the clot by cross‑linking fibrin fibers between the side chains of specific lysine and glutamine residues in fibrinogen alpha and gamma chains (Mattheij NJA 2016; Kotova YN et al., 2019). This Reactome event shows FXIIIa-mediated cross‑linking of fibrin fibers bound to αIIbβ3 (ITGA2B:ITGB3) on the platelet surface.
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| (summation) | [BlackBoxEvent:9921091] αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+ [Homo sapiens] |
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