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Details on Person αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+

Class:Id	BlackBoxEvent:9921091
_displayName	αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+
_doRelease	TRUE
_timestamp	2026-01-27 16:21:00
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
catalystActivity	[CatalystActivity:140850] protein-glutamine gamma-glutamyltransferase activity of factor XIIIa [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9921099] Shamovsky, Veronica, 2024-09-05
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[Complex:114559] Integrin alpha IIb beta 3:fibrin multimer [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[Book:140853] 9780192616616 The Molecular Genetics of Haemostasis and Its Inherited Disorders Tuddenham, EG [LiteratureReference:9921065] Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen [LiteratureReference:9921038] Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII
modified	[InstanceEdit:9933757] Shamovsky, Veronica, 2025-01-03 [InstanceEdit:9935058] Shamovsky, Veronica, 2025-01-12 [InstanceEdit:9938640] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938677] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938866] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979580] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980358] Shamovsky, Veronica, 2026-01-27
name	αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+ ITGA2B:ITGB3:fibrin multimer ->ITGA2B:ITGB3:fibrin multimer, crosslinked + NH4+
output	[SimpleEntity:140912] NH4+ [extracellular region] [Complex:9933756] αIIbβ3:fibrin multimer, crosslinked [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:140847] factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain [Homo sapiens] [Reaction:140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides [Homo sapiens] [Reaction:481009] Exocytosis of platelet dense granule content [Homo sapiens] [Reaction:114560] Adhesion of integrin αIIbβ3 to fibrin network [Homo sapiens] [Reaction:140842] n fibrin monomers -> fibrin multimer [Homo sapiens]
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9921100] R-HSA-9921091.1
structureModified	[InstanceEdit:9933757] Shamovsky, Veronica, 2025-01-03
summation	[Summation:9921092] Upon clot formation, fibrin multimers bind activated αIIbβ3 ...
(hasEvent)	[Pathway:9769733] Fibrin formation [Homo sapiens]
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No pathways have been reviewed or authored by αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+ (9921091)