Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NS2B binds CGAS

Class:IdReaction:9920882
_displayNameNS2B binds CGAS
_doReleaseTRUE
_timestamp2025-10-30 11:46:34
authored[InstanceEdit:9920766] Stephan, Ralf, 2024-09-03
compartment[Compartment:70101] cytosol
created[InstanceEdit:9920810] Stephan, Ralf, 2024-09-04
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
input[EntityWithAccessionedSequence:3244653] CGAS [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9918774] NS2B [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9970111] Orlic-Milacic, Marija, 2025-10-27
isChimericFALSE
literatureReference[LiteratureReference:9920859] Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection
modified[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925705] Stephan, Ralf, 2024-10-22
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964206] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966337] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameNS2B binds CGAS
output[Complex:9920820] NS2B:CGAS [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
[InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9920885] R-HSA-9920882.1
summation[Summation:9920821] DENV NS2B binds to cyclic GMP-AMP synthase (CGAS, MB21D1), l...
(hasEvent)[Pathway:9920588] Dengue virus activates/modulates innate and adaptive immune responses [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NS2B binds CGAS (9920882)