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Details on Person p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus

Class:Id	BlackBoxEvent:9920665
_displayName	p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus
_doRelease	TRUE
_timestamp	2025-02-18 21:14:09
authored	[InstanceEdit:9920688] May, Bruce, 2024-08-15
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9920722] May, Bruce, 2024-09-03
edited	[InstanceEdit:9920688] May, Bruce, 2024-08-15
inferredFrom	[BlackBoxEvent:9926582] p-S97-Bmal1:p-T451,T461-Clock translocates from the cytosol to the nucleoplasm [Mus musculus]
input	[Complex:9912404] p-S90-BMAL1:p-T451,T461-CLOCK [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
modified	[InstanceEdit:9925663] May, Bruce, 2024-10-21 [InstanceEdit:9926648] May, Bruce, 2024-11-01 [InstanceEdit:9929342] May, Bruce, 2024-11-24 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus
output	[Complex:9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9912390] p-S90-BMAL1 binds p-T451,T461-CLOCK [Homo sapiens] [Reaction:9912401] CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 [Homo sapiens] [Reaction:9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9920745] R-HSA-9920665.1
structureModified	[InstanceEdit:9925663] May, Bruce, 2024-10-21
summation	[Summation:9929288] The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer tra...
(hasEvent)	[Pathway:9931529] Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK [Homo sapiens]
(precedingEvent)	[Reaction:5663105] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE41 (DEC2) gene [Homo sapiens] [Reaction:5663122] p-S90-BMAL1:p-T451,T461-CLOCK binds NAMPT gene [Homo sapiens] [Reaction:5663124] p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene [Homo sapiens] [Reaction:5663127] p-S90-BMAL1:p-T451,T461-CLOCK,NPAS2 binds F7 gene [Homo sapiens] [Reaction:5663138] p-S90-BMAL1:p-T451,T461-CLOCK binds CCRN4L (NOCTURNIN) gene [Homo sapiens] [Reaction:5663156] p-S90-BMAL1:p-T451,T461-CLOCK binds PPARA gene [Homo sapiens] [Reaction:5663165] p-S90-BMAL1:p-T451,T461-CLOCK binds AVP gene [Homo sapiens] [Reaction:5663170] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE40 gene [Homo sapiens] [Reaction:8878683] p-S90-BMAL1:p-T451,T461-CLOCK binds KLF10 gene [Homo sapiens] [Reaction:8878702] p-S90-BMAL1:p-T451,T461-CLOCK binds KLF15 gene [Homo sapiens] List all 21 refering instances
(replacementInstances)	[_Deleted:9938750] Deletion of instance: 421320 [_Deleted:9939502] Deletion of instance: 508656
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No pathways have been reviewed or authored by p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus (9920665)