Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person Secreted NS1 binds to other cell
Class:Id BlackBoxEvent:9920147
_displayName Secreted NS1 binds to other cell
_doRelease TRUE
_timestamp 2025-10-30 11:56:32
authored [InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
compartment [Compartment:984] extracellular region [Compartment:876] plasma membrane
created [InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
disease [Disease:3244610] dengue disease
edited [InstanceEdit:9970471] Stephan, Ralf, 2025-10-30
goBiologicalProcess [GO_BiologicalProcess:1221375] protein localization to plasma membrane
input [Complex:9919955] NS1:HDL [extracellular region] [Homo sapiens]
internalReviewed [InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23 [InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric FALSE
literatureReference [LiteratureReference:9920076] Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E
modified [InstanceEdit:9920561] Stephan, Ralf, 2024-09-01 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925705] Stephan, Ralf, 2024-10-22 [InstanceEdit:9925766] Stephan, Ralf, 2024-10-24 [InstanceEdit:9945238] Stephan, Ralf, 2025-04-12 [InstanceEdit:9960000] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960005] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960006] Stephan, Ralf, 2025-07-04 [InstanceEdit:9962306] Stephan, Ralf, 2025-08-03 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964208] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966338] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name Secreted NS1 binds to other cell
output [Complex:9920090] NS1 hexamer lipoparticle [plasma membrane] [Dengue virus type 2] [Complex:265523] spherical HDL [extracellular region] [Homo sapiens]
precedingEvent
previousReviewStatus [ReviewStatus:9821383] three stars
regulatedBy [PositiveRegulation:9837623] Positive regulation by 'HSPGs [plasma membrane]'
regulationReference [RegulationReference:9925710] Positive regulation by 'HSPGs [plasma membrane]' Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E
relatedSpecies [Species:3244621] Dengue virus type 2
releaseDate 2025-12-08
reviewed [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29 [InstanceEdit:9970204] Mansur, Daniel Santos, 2025-10-29
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9920194] R-HSA-9920147.1
structureModified [InstanceEdit:9925705] Stephan, Ralf, 2024-10-22 [InstanceEdit:9945238] Stephan, Ralf, 2025-04-12
summation [Summation:9920080] Soluble NS1 binds to the surface of uninfected cells, primar...
(hasEvent) [Pathway:9918481] Dengue Virus-Host Interactions [Homo sapiens]
(precedingEvent) [Reaction:9920623] NS1 binds C4BP [Homo sapiens] [Reaction:9921198] NS1 binds MMP9 and CTNNB1 [Homo sapiens] [Reaction:9921202] NS1 binds MMP9 and TJP1 [Homo sapiens] [Reaction:9921458] NS1 binds TLR4 [Homo sapiens] [Reaction:9921484] NS1 binds KIR3DL1 [Homo sapiens] [BlackBoxEvent:9921695] NS1 gets endocytosed [Homo sapiens]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by Secreted NS1 binds to other cell (9920147)