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Class:Id BlackBoxEvent:9920087 _displayName Nonstructural proteins form the replication complex _doRelease TRUE _timestamp 2026-03-03 08:58:19 authored [InstanceEdit:9919049] Stephan, Ralf, 2024-08-19 compartment [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane created [InstanceEdit:9920038] Stephan, Ralf, 2024-08-29 disease [Disease:3244610] dengue disease edited [InstanceEdit:9966335] Stephan, Ralf, 2025-09-18 goBiologicalProcess [GO_BiologicalProcess:26392] viral replication complex formation and maintenance input [EntityWithAccessionedSequence:9918814] NS4A [endoplasmic reticulum membrane] [Dengue virus type 2] [Complex:9921293] NS1 dimer [cytosol] [Dengue virus type 2] [EntityWithAccessionedSequence:9918774] NS2B [endoplasmic reticulum membrane] [Dengue virus type 2] [EntityWithAccessionedSequence:9918789] NS2A [endoplasmic reticulum membrane] [Dengue virus type 2] [Complex:9924284] NS4B dimer [endoplasmic reticulum membrane] [Dengue virus type 2] [Complex:9979853] NS3:NS5 [endoplasmic reticulum membrane] [Dengue virus type 2] [Complex:9979853] NS3:NS5 [endoplasmic reticulum membrane] [Dengue virus type 2] internalReviewed [InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23 [InstanceEdit:9959999] Matthews, Lisa, 2025-07-04 [InstanceEdit:9978780] D'Eustachio, Peter, 2026-01-06 isChimeric FALSE literatureReference [LiteratureReference:9919995] Molecular Insights into the Flavivirus Replication Complex [LiteratureReference:9920127] The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner [LiteratureReference:9920067] Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B [LiteratureReference:9922742] Shaping the flavivirus replication complex: It is curvaceous! [LiteratureReference:9922754] Membrane-Associated Flavivirus Replication Complex-Its Organization and Regulation [LiteratureReference:9922939] Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface [LiteratureReference:9922934] Dengue virus nonstructural protein 5 adopts multiple conformations in solution [LiteratureReference:9947484] Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1 [LiteratureReference:9946498] Flavivirus recruits the valosin-containing protein-NPL4 complex to induce stress granule disassembly for efficient viral genome replication [LiteratureReference:9948054] Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis [LiteratureReference:9948052] Targeting host lipid flows: Exploring new antiviral and antibiotic strategies [LiteratureReference:9948059] The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling [LiteratureReference:9948113] The entanglement between flaviviruses and ER-shaping proteins [LiteratureReference:9948109] ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly [LiteratureReference:9948090] Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein [LiteratureReference:9948097] Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections [LiteratureReference:9949484] RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication [LiteratureReference:9946398] K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B [LiteratureReference:9975711] Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model modified [InstanceEdit:9920949] Stephan, Ralf, 2024-09-05 [InstanceEdit:9921340] Stephan, Ralf, 2024-09-09 [InstanceEdit:9922740] Stephan, Ralf, 2024-09-26 [InstanceEdit:9922933] Stephan, Ralf, 2024-09-27 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924280] Stephan, Ralf, 2024-10-13 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925765] Stephan, Ralf, 2024-10-24 [InstanceEdit:9946397] Stephan, Ralf, 2025-04-24 [InstanceEdit:9947487] Stephan, Ralf, 2025-05-06 [InstanceEdit:9947693] Stephan, Ralf, 2025-05-11 [InstanceEdit:9948034] Stephan, Ralf, 2025-05-15 [InstanceEdit:9948061] Stephan, Ralf, 2025-05-15 [InstanceEdit:9948079] Stephan, Ralf, 2025-05-16 [InstanceEdit:9948204] Stephan, Ralf, 2025-05-17 [InstanceEdit:9949486] Stephan, Ralf, 2025-05-22 [InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9960000] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960003] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964208] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966338] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30 [InstanceEdit:9975716] Stephan, Ralf, 2025-12-02 [InstanceEdit:9978772] Stephan, Ralf, 2026-01-06 [InstanceEdit:9978781] D'Eustachio, Peter, 2026-01-06 [InstanceEdit:9978783] D'Eustachio, Peter, 2026-01-06 [InstanceEdit:9979852] Stephan, Ralf, 2026-01-22 [InstanceEdit:9979858] Stephan, Ralf, 2026-01-22 [InstanceEdit:9984050] Stephan, Ralf, 2026-03-03 name Nonstructural proteins form the replication complex output [Complex:9979859] Replication complex (RC) [endoplasmic reticulum membrane] [Dengue virus type 2] precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars regulatedBy [NegativeRegulation:9946392] Negative regulation by 'K48polyUb-NS1 dimer [cytosol]' [Requirement:9947483] Requirement by 'SUN2 [nuclear envelope]' [Requirement:9948040] Requirement by 'NS3:FASN [cytosol]' [PositiveRegulation:9948063] Positive regulation by 'RTN3 [endoplasmic reticulum membrane]' [PositiveRegulation:9948106] Positive regulation by 'ATL2 [endoplasmic reticulum membrane]' [Requirement:9948195] Requirement by 'NS4A:p39-VIM [endoplasmic reticulum membrane]' [NegativeRegulation:9975717] Negative regulation by 'mosnodenvir [cytosol]' regulationReference [RegulationReference:9922757] Requirement by 'DNAJC14 [endoplasmic reticulum membrane]' Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator [RegulationReference:9946384] Negative regulation by 'K48polyUb-NS1 dimer [cytosol]' K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B [RegulationReference:9978771] Negative regulation by 'mosnodenvir [cytosol]' Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model relatedSpecies [Species:3244621] Dengue virus type 2 releaseDate 2025-12-08 reviewed [InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29 [InstanceEdit:9978784] D'Eustachio, Peter, 2026-01-06 [InstanceEdit:9984049] Roque Ascenção, Fernando, 2026-03-03 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9920177] R-HSA-9920087.2 structureModified [InstanceEdit:9920949] Stephan, Ralf, 2024-09-05 [InstanceEdit:9921340] Stephan, Ralf, 2024-09-09 [InstanceEdit:9922740] Stephan, Ralf, 2024-09-26 [InstanceEdit:9922933] Stephan, Ralf, 2024-09-27 [InstanceEdit:9924280] Stephan, Ralf, 2024-10-13 [InstanceEdit:9946397] Stephan, Ralf, 2025-04-24 [InstanceEdit:9947487] Stephan, Ralf, 2025-05-06 [InstanceEdit:9947693] Stephan, Ralf, 2025-05-11 [InstanceEdit:9948034] Stephan, Ralf, 2025-05-15 [InstanceEdit:9948061] Stephan, Ralf, 2025-05-15 [InstanceEdit:9948079] Stephan, Ralf, 2025-05-16 [InstanceEdit:9948204] Stephan, Ralf, 2025-05-17 [InstanceEdit:9975716] Stephan, Ralf, 2025-12-02 [InstanceEdit:9979852] Stephan, Ralf, 2026-01-22 [InstanceEdit:9979858] Stephan, Ralf, 2026-01-22 summation [Summation:9920061] From localization and functional experiments, it can be conc... (hasEvent) [Pathway:9918487] Dengue Virus Genome Translation and Replication [Homo sapiens] (precedingEvent) [Reaction:9922961] DENV genomic RNA binds Replication Complex [Homo sapiens] (updatedInstance) [_UpdateTracker:9984583] Update Tracker - [BlackBoxEvent:9920087] Nonstructural proteins form the replication complex - v96:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference, removeRegulator]
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No pathways have been reviewed or authored by Nonstructural proteins form the replication complex (9920087)
