Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NS1 dimer localizes to the cell membrane

Class:IdReaction:9920051
_displayNameNS1 dimer localizes to the cell membrane
_doReleaseTRUE
_timestamp2025-10-30 11:46:04
authored[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:876] plasma membrane
created[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input[Complex:9920022] NS1 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] [Dengue virus type 2]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9920031] Association of dengue virus NS1 protein with lipid rafts
modified[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925761] Stephan, Ralf, 2024-10-23
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964206] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966337] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameNS1 dimer localizes to the cell membrane
output[Complex:9919961] NS1 dimer [plasma membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9920155] R-HSA-9920051.1
summation[Summation:9920035] In HEK-293T cells part of the NS1 dimer localizes to lipid r...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9920071] Secreted NS1 binds to HDL [Homo sapiens]
[Reaction:9947535] NS1 dimer associates with exosomes [Homo sapiens]
[Reaction:9956857] Domperidone binds NS1 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NS1 dimer localizes to the cell membrane (9920051)