Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NS5 is exported from nucleus

Class:IdBlackBoxEvent:9920046
_displayNameNS5 is exported from nucleus
_doReleaseTRUE
_timestamp2025-10-30 11:53:24
authored[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
disease[Disease:3244610] dengue disease
edited[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess[GO_BiologicalProcess:160102] nuclear export
input[EntityWithAccessionedSequence:9920123] NS5 [nucleoplasm] [Dengue virus type 2]
internalReviewed[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimericFALSE
literatureReference[LiteratureReference:9920009] CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production
modified[InstanceEdit:9920209] Stephan, Ralf, 2024-08-29
[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07
[InstanceEdit:9924657] Stephan, Ralf, 2024-10-16
[InstanceEdit:9925761] Stephan, Ralf, 2024-10-23
[InstanceEdit:9947750] Stephan, Ralf, 2025-05-13
[InstanceEdit:9963605] Stephan, Ralf, 2025-08-15
[InstanceEdit:9964208] Stephan, Ralf, 2025-08-20
[InstanceEdit:9966303] Stephan, Ralf, 2025-09-15
[InstanceEdit:9966334] Stephan, Ralf, 2025-09-18
[InstanceEdit:9966338] Stephan, Ralf, 2025-09-19
[InstanceEdit:9970207] Stephan, Ralf, 2025-10-29
[InstanceEdit:9970441] Stephan, Ralf, 2025-10-30
[InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
nameNS5 is exported from nucleus
output[EntityWithAccessionedSequence:9920129] NS5 [endoplasmic reticulum membrane] [Dengue virus type 2]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[Requirement:5687133] Requirement by 'XPO1 [nucleoplasm]'
relatedSpecies[Species:3244621] Dengue virus type 2
releaseDate2025-12-08
reviewed[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18
[InstanceEdit:9970439] Roque Ascenção, Fernando, 2025-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9920169] R-HSA-9920046.1
structureModified[InstanceEdit:9920209] Stephan, Ralf, 2024-08-29
summation[Summation:9920207] A portion of nucleus-localized Dengue virus (DENV) NS5 prote...
(hasEvent)[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)[Reaction:9920215] NS5 binds NS3 [Homo sapiens]
[Reaction:9920829] NS5 binds HSP90 [Homo sapiens]
[Reaction:9920878] NS5 binds STAT2 [Homo sapiens]
[Reaction:9920957] NS5 binds UBR4 [Homo sapiens]
[Reaction:9947739] NS5 binds mTORC1,2 [Homo sapiens]
[Reaction:9947747] NS5 binds GBF1 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NS5 is exported from nucleus (9920046)
Follow Reactome