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Details on Person PKG phosphorylates NS5

Class:Id	Reaction:9920025
_displayName	PKG phosphorylates NS5
_doRelease	TRUE
_timestamp	2025-10-30 11:55:05
authored	[InstanceEdit:9919049] Stephan, Ralf, 2024-08-19
catalystActivity	[CatalystActivity:9920145] cGMP-dependent protein kinase activity of Activated cGMP-dependent protein kinase (PKGs) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29
crossReference	[DatabaseIdentifier:9857129] RHEA:46609
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
inferredFrom	[Reaction:9954423] PKG phosphorylates NS5 [Bos taurus]
input	[EntityWithAccessionedSequence:9918834] pre-NS5 [endoplasmic reticulum membrane] [Dengue virus type 2] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9920119] Protein kinase G phosphorylates mosquito-borne flavivirus NS5 [LiteratureReference:9920023] Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5
modified	[InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925761] Stephan, Ralf, 2024-10-23 [InstanceEdit:9954417] Stephan, Ralf, 2025-06-07 [InstanceEdit:9960009] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964208] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966338] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	PKG phosphorylates NS5
output	[EntityWithAccessionedSequence:9919971] p-NS5 [endoplasmic reticulum membrane] [Dengue virus type 2] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9918823] NS345:NS2B cleaves NS345 [Homo sapiens] [Reaction:9918798] NS2B binds to NS345 [Homo sapiens] [Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens] [Reaction:9947496] ACOT2 cleaves NS345 [Homo sapiens] [Reaction:9918798] NS2B binds to NS345 [Homo sapiens] [Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9920178] R-HSA-9920025.1
summation	[Summation:9954418] NS5 from DENV-2 (strain U87411) is phosphorylated at Thr-449...
(hasEvent)	[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)	[Reaction:9919982] NS5 is glutathionylated [Homo sapiens]
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No pathways have been reviewed or authored by PKG phosphorylates NS5 (9920025)