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Details on Person E is N-glycosylated

Class:Id	BlackBoxEvent:9918962
_displayName	E is N-glycosylated
_doRelease	TRUE
_timestamp	2025-10-30 11:40:45
authored	[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18
catalystActivity	[CatalystActivity:532535] dolichyl-diphosphooligosaccharide-protein glycotransferase activity of OST complex [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9918965] Stephan, Ralf, 2024-08-19
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
goBiologicalProcess	[GO_BiologicalProcess:5147] protein N-linked glycosylation
input	[SimpleEntity:1131311] a nucleotide sugar [cytosol] [SimpleEntity:1131311] a nucleotide sugar [cytosol] [EntityWithAccessionedSequence:9918820] pre-E [endoplasmic reticulum membrane] [Dengue virus type 2]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23 [InstanceEdit:9959999] Matthews, Lisa, 2025-07-04
isChimeric	FALSE
literatureReference	[LiteratureReference:9918992] Dengue Virus Glycosylation: What Do We Know? [LiteratureReference:9918958] Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapy [LiteratureReference:9918966] Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes [LiteratureReference:9918944] N-linked glycans on dengue viruses grown in mammalian and insect cells [LiteratureReference:9918986] Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection [LiteratureReference:9918979] Characterization of N-Glycan Structures on the Surface of Mature Dengue 2 Virus Derived from Insect Cells [LiteratureReference:9918994] Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis [LiteratureReference:9918976] Site-specific characterization of envelope protein N-glycosylation on Sanofi Pasteur's tetravalent CYD dengue vaccine [LiteratureReference:9945576] Glycosylation of viral proteins: Implication in virus-host interaction and virulence [LiteratureReference:9945752] Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus [LiteratureReference:9947389] CRISPR Screen Reveals PACT as a Pro-Viral Factor for Dengue Viral Replication [LiteratureReference:9948197] A Genome-Wide CRISPR-Cas9 Screen Identifies the Dolichol-Phosphate Mannose Synthase Complex as a Host Dependency Factor for Dengue Virus Infection
modified	[InstanceEdit:9920038] Stephan, Ralf, 2024-08-29 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925441] Stephan, Ralf, 2024-10-17 [InstanceEdit:9925761] Stephan, Ralf, 2024-10-23 [InstanceEdit:9945736] Stephan, Ralf, 2025-04-17 [InstanceEdit:9947356] Stephan, Ralf, 2025-05-05 [InstanceEdit:9948204] Stephan, Ralf, 2025-05-17 [InstanceEdit:9959795] Stephan, Ralf, 2025-07-02 [InstanceEdit:9960000] Stephan, Ralf, 2025-07-04 [InstanceEdit:9960003] Stephan, Ralf, 2025-07-04 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964208] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966304] Stephan, Ralf, 2025-09-15 [InstanceEdit:9966309] Stephan, Ralf, 2025-09-16 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966337] Stephan, Ralf, 2025-09-19 [InstanceEdit:9967800] D'Eustachio, Peter, 2025-10-07 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	E is N-glycosylated
output	[SimpleEntity:9684302] nucleoside 5'-diphosphate(3-) [cytosol] [SimpleEntity:9684302] nucleoside 5'-diphosphate(3-) [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [EntityWithAccessionedSequence:9918952] 2xN4GlycoAsn-E [endoplasmic reticulum-Golgi intermediate compartment membrane] [Dengue virus type 2]
precedingEvent	[BlackBoxEvent:9918795] Signalase cleaves prM-E-NS1-NS2A [Homo sapiens] [BlackBoxEvent:9918787] NS2B3 cleaves C-prM-E-NS1-NS2A [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:9948200] Requirement by 'DPM1:DPM2:DPM3 [endoplasmic reticulum membrane]'
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9919003] R-HSA-9918962.1
structureModified	[InstanceEdit:9947356] Stephan, Ralf, 2025-05-05 [InstanceEdit:9948204] Stephan, Ralf, 2025-05-17
summation	[Summation:9918984] DENV-2 E protein is known to be N-glycosylated at Asn-67 and...
(hasEvent)	[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9919009] NMT1 interacts with E [Homo sapiens]
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No pathways have been reviewed or authored by E is N-glycosylated (9918962)