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Details on Person NS2B3 cleaves prepro-C at the C-prM junction

Class:Id	Reaction:9918876
_displayName	NS2B3 cleaves prepro-C at the C-prM junction
_doRelease	TRUE
_timestamp	2025-10-30 11:48:19
authored	[InstanceEdit:9918869] Stephan, Ralf, 2024-08-18
catalystActivity	[CatalystActivity:9919951] serine-type endopeptidase activity of NS2B3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9918874] Stephan, Ralf, 2024-08-18
disease	[Disease:3244610] dengue disease
edited	[InstanceEdit:9966335] Stephan, Ralf, 2025-09-18
input	[EntityWithAccessionedSequence:9918872] prepro-C [cytosol] [Dengue virus type 2] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9925762] Orlic-Milacic, Marija, 2024-10-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9918797] Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses
modified	[InstanceEdit:9918886] Stephan, Ralf, 2024-08-18 [InstanceEdit:9920038] Stephan, Ralf, 2024-08-29 [InstanceEdit:9920209] Stephan, Ralf, 2024-08-29 [InstanceEdit:9920810] Stephan, Ralf, 2024-09-04 [InstanceEdit:9924077] Stephan, Ralf, 2024-10-07 [InstanceEdit:9924657] Stephan, Ralf, 2024-10-16 [InstanceEdit:9925761] Stephan, Ralf, 2024-10-23 [InstanceEdit:9939564] Stephan, Ralf, 2025-02-28 [InstanceEdit:9963605] Stephan, Ralf, 2025-08-15 [InstanceEdit:9964206] Stephan, Ralf, 2025-08-20 [InstanceEdit:9966309] Stephan, Ralf, 2025-09-16 [InstanceEdit:9966334] Stephan, Ralf, 2025-09-18 [InstanceEdit:9966339] Stephan, Ralf, 2025-09-19 [InstanceEdit:9970207] Stephan, Ralf, 2025-10-29 [InstanceEdit:9970441] Stephan, Ralf, 2025-10-30 [InstanceEdit:9970472] Stephan, Ralf, 2025-10-30
name	NS2B3 cleaves prepro-C at the C-prM junction
output	[EntityWithAccessionedSequence:9918825] C [cytosol] [Dengue virus type 2] [EntityWithAccessionedSequence:9918878] Fragment [cytosol] [Dengue virus type 2]
precedingEvent	[BlackBoxEvent:9918787] NS2B3 cleaves C-prM-E-NS1-NS2A [Homo sapiens] [Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens] [Reaction:9918807] NS2B binds NS3 [Homo sapiens] [Reaction:9918807] NS2B binds NS3 [Homo sapiens] [Reaction:9918817] NS2B3 cleaves polyprotein [Homo sapiens] [Reaction:9918772] Dengue polyprotein cis-auto-cleaves [Homo sapiens] [Reaction:9918823] NS345:NS2B cleaves NS345 [Homo sapiens] [BlackBoxEvent:9945766] NS3 is ubiquitinated [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
relatedSpecies	[Species:3244621] Dengue virus type 2
releaseDate	2025-12-08
reviewed	[InstanceEdit:9966332] Mansur, Daniel Santos, 2025-09-18 [InstanceEdit:9970439] Roque Ascen��o, Fernando, 2025-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9918884] R-HSA-9918876.1
summation	[Summation:9920205] Dengue virus NS2B:NS3 (NS2B3) peptidase cleaves prepro-C at ...
(hasEvent)	[Pathway:9918432] Maturation of DENV proteins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9920843] C binds TRIM25 [Homo sapiens] [Reaction:9921319] C binds EXOC1 [Homo sapiens] [Reaction:9921869] C binds PEX19 [Homo sapiens] [Reaction:9922227] C forms a dimer [Homo sapiens]
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No pathways have been reviewed or authored by NS2B3 cleaves prepro-C at the C-prM junction (9918876)